摘要
目的观察枸橼酸坦度螺酮对精神分裂症患者的疗效和记忆功能的影响。方法回顾性分析广东省惠州市第二人民医院80例患者的临床资料,将其分为观察组和对照组,各40例,安慰剂清洗2周后,两组患者均给予非典型抗精神病药。观察组在此基础上给予枸橼酸坦度螺酮30 mg/d,每天3次;对照组给予等量安慰剂胶囊,两组均治疗8周。采用PANSS评分评价疗效,用韦氏记忆量表(WMS-R)评价患者的记忆功能,用药物副反应量表(TESS)评定药物的不良反应。结果观察组的总有效率为92.5%,显著高于对照组的70.0%(P<0.05);两组治疗后的第6周和第8周PANSS总分和各因子评分明显降低,观察组总分[(50.6±7.8)、(45.8±6.8)分]、阳性症状评分[(14.2±3.9)、(10.1±4.7)分]和阴性症状评分[(12.5±4.3)、(11.3±3.8)分]低于同期对照组[(65.4±9.3)、57.5±9.2)分,(19.3±5.8)、(17.8±5.4)分,(16.6±4.5)、(14.7±4.8)分](P<0.05);治疗后观察组WMS-R测试结果显著改善[(90.64±13.26)分比(103.53±14.33)分],对照组无明显改变[(91.25±12.87)分比(94.16±13.25)分];两组患者治疗过程中的不良反应发生率(17.5%比15.0%)和TESS评分[(3.52±1.16)分比(3.47±1.21)分]无明显差别。结论枸橼酸坦度螺酮治疗精神分裂症具有良好的疗效,而且可以改善患者的记忆功能,且不良反应少,值得临床推广。
Objective To observe the clinical effect and changes of memory function in patients with schizophrenia be ing treated with Tandospirone Citrate.Methods 80 cases of patients were randomly divided into test group and control group,40 cases in each group.The two groups of patients were treated with atypical antipsychotics after clean by placebo for 2 weeks.The test group was given 30 mg of Tandospirone Citrate per day,and the control group was given equal placebo capsules,both groups were treated for 8 weeks.PANSS and WMS-R were used to evaluate efficacy and memory function of the patients,and TESS was used to assessment the adverse reactions.Results The total effective rate of test group was 92.5%,significantly higher than 70.0% of control group（P ＆lt; 0.05）.The PANSS total score and each factor score were significantly reduced after treatment for 6 and 8 weeks,the total score [（50.6 ±7.8）,（45.8±6.8） points],positive symptoms [（14.2 ±3.9）,（10.1 ±4.7） points] and negative symptoms score [（12.5 ±4.3）,（11.3 ±3.8） points] of the test group were lower than control group [（65.4±9.3）,（57.5±9.2） points;（19.3±5.8）,（17.8±5.4） points;（16.6±4.5）,（14.7± 4.8） points]（P ＆lt; 0.05）.The WMS-R test results of test group was improved significantly after treatment [（90.64 ±13.26） points vs（103.53±14.33） points],but there was no significantly change in control group [（91.25±12.87） points vs（94.16± 13.25） points].There was no significant difference of incidence of adverse reactions and TESS scores in the two groups [17.5% vs 15.0%,（3.52±1.16） points vs（3.47±1.21） points].Conclusion The clinical effect on treatment with Tandospirone Citrate for schizophrenia patients is satisfactory,which can improve memory function of the patients and has fewer adverse reactions,which is worthy of clinical use.
出处
《中国医药导报》
CAS
2013年第17期83-85,共3页
China Medical Herald
基金
广东省惠州市科技计划项目(编号2012Y090)
