摘要
清热类中药为中医临床防治缺血性心脏病的常用中药之一。近年来,许多文献报道表明,清热类中药中的黄连、黄芩、金银花、虎杖、赤芍、竹叶,以及复方中的金银花制剂、黄连解毒汤等对于心肌缺血模型动物具有明显的减少心肌梗死面积的作用,其作用机制涉及多个方面,如抗氧化应激反应、改善细胞线粒体功能、抑制心肌细胞凋亡等。在缺血性心血管疾病已成为严重威胁我国人民生命安全的重大疾病的今天,对于清热类中药防治心血管疾病的药理作用和机制研究,将为开发高效、安全的防治心血管疾病的中药新药奠定坚实的基础。
Anti-fever Chinese herb is a kind of common used Chi- nese medicine in clinical treatment of ischemic heart disease. In recent years, it is reported in many literature that single herb, such as coptis chinensis, scutellaria baicalensis, honeysuckle, polygonum cuspidatum, radix paeonia rubra and herba lo- phatheri, and the compound, such as honeysuckle preparations and huanglian jiedu decoction, myocardial infarct area on rats and compound prescription has tioxidative response, improving have distinct effect of reducing The mechanism of these herbs multifaceted roles, such as an- mitochondrial features, and inhibiting apoptosis of myocardial cell, etc. Nowadays, ischemie cardiovascular diseases have become a major disease and a seri- ous threat to people＇s lives in our country. The research of phar- maceutical effect and mechanism of anti-fever Chinese herbs would lay a solid foundation for developing effective and safe Chi- nese medicine for prevention and treatment of cardiovascular disease.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2013年第7期1026-1029,共4页
Chinese Pharmacological Bulletin
基金
国家"重大新药创制"科技重大专项"十一五"及"十二五"计划课题(No 2011ZX09401-014
2012ZX09103201-012)
关键词
清热药
复方
心肌缺血
再灌注损伤
抗氧化
细胞
凋亡
缺血性心脏病
anti-fever Chinese herbs
compound prescription
myocardial isehemia-reperfusion injury
antioxidant
apoptosis
ischemic heart disease
