摘要
目的分析血清IgG4水平对原发性膜性肾病（IMN）诊断及其与继发性膜性肾病（SMN）患者诊断和鉴别诊断的意义。方法检测28例膜性肾病患者（其中IMN21例，SMN7例）血清IgG4水平，并行尿蛋白测定及相关血生化检测，对其结果进行分析比较。结果IMN组和SMN组血清IgG4水平（分别为2373．86．g／L±1156．59ng／L和1321．57ng／L±1330．28ng／L）比较有显著性差异（P〈0．01），两组尿蛋白定量（分别为6．46g／a±6．41g／d和5．74g／d±3．53g／d）比较无显著性差异（P〉0．05），而两组主要血生化指标比较也无显著差异（P〉0．05）。结论血清IgG4水平检测可作为临床IMN的诊断及其与SMN鉴别诊断的指标之一。
Objectives To explore the clinical significance of seruro IgG4 in the diagnosis and differential diagnosis of idiopathic membranous nephrepathy （ IMN ） and secondary membranous nephropathy（SMN）. Methods The serum IgG4 concentrations of 21 IMN patients and 7 SMN patients were detected by ELISA, urinary protein concentrations and main serum biochemistry parameters were measured, and analysed their correlation. Results The serum IgG4 levels of IMN patients are significantly higher than the SMN patients, （2373.86 ng/L ＋ 1156.59 ng/ L and 1321.57 ng/L ± 1330.28 ng/L,respectively,P 〈0.01 ） ;urinary protein concentrations of two groups （6.46 g/ d ± 6.41 g/d and 5.74 g/d ± 3.53 g/d, respectively）and main serum biochemistry parameters have no significant difference（ P 〉 0.05 ）. Conclusions Serum IgG4 might be a useful indicator to diagnosis and differential diagnosis of IMN and SMN.
出处
《国际泌尿系统杂志》
2013年第3期314-316,共3页
International Journal of Urology and Nephrology
