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选择性COX-2抑制剂在髋关节置换术围术期镇痛中的应用 被引量：11

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摘要 目的观察塞来昔布超前镇痛及帕瑞昔布钠术后镇痛在髋关节置换术围术期镇痛中的疗效及探讨其作用机制。方法择期行髋关节置换术96例随机分为实验组、对照组。实验组在术前2 h给予塞来昔布400 mg口服,术后即刻肌注帕瑞昔布钠40 mg,以后每隔12 h注射1次、共6次,进行术后镇痛。对照组在术后使用自控式静脉镇痛泵镇痛。术前与术后测定血清中环氧合酶(COX)-2和前列腺素E2(PGE2)水平,记录VAS评分、术中出血量、术后切口引流量。结果实验组VAS评分、术后血清PGE2和COX-2水平均低于对照组;术中出血量、切口引流量及药物不良反应发生率两组差异无统计学意义。结论髋关节置换术患者术前口服塞来昔布进行超前镇痛,术后即刻肌注帕瑞昔布钠进行术后镇痛,其镇痛效果优于自控式静脉镇痛泵;围术期应用上述药物能显著抑制手术创伤引起的PGE2与COX-2的释放。
作者 张金山 李毅中
机构地区 晋江市医院骨科 福建医科大学附属第二医院骨科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2013年第11期2514-2516,共3页 Chinese Journal of Gerontology
关键词 超前镇痛 塞来昔布 帕瑞昔布钠 环氧合酶2 前列腺素E2
分类号 R687.4 [医药卫生—骨科学]
  • 相关文献

参考文献10

  • 1鲁昕,邱贵兴.围手术期镇痛在骨关节手术中的新进展[J].中国矫形外科杂志,2009,17(24):1873-1875. 被引量：37
  • 2Wheeler M,Oderda GM,Ashburm MA,et al.Adverse events associatedwith postoperative opioid analgesia: a systematic review [ J ] .J Pain,2002;3(3):15940.
  • 3Apfelbaum JL, Chen C, Gan TJ,ef al.Postoperative pain experience: re-sults from a national survey suggest postoperative pain continues to be un-dermanaged [J}.Anesth Analg,2003,97(2): 534-40.
  • 4Buvanendran A,Kroin JS, Tuman KJ,et al.Effects of perioperative ad-ministration of a selective cyclooxygenase 2 inhibitor on pain managementand recovery of function after knee replacement: a randomized controlledtrial[ J].JAMA,2003,290(8):2411-8.
  • 5沈奕,张湘生.塞来昔布在骨节段转移术中的超前镇痛作用研究[J].国际骨科学杂志,2009,30(3):194-196. 被引量：9
  • 6张金山,李毅中.塞来昔布预先镇痛与帕瑞昔布钠术后镇痛在脊柱手术围术期的应用[J].实用疼痛学杂志,2011,7(5):339-342. 被引量：3
  • 7Riest G,Peters J, Weiss M,et al.Preventive effects of perioperative pare-coxib on post-discectomy pain[J].Br J Anaesth,2008, 100(2):256-62.
  • 8Jirarattanaphocha IK, Thienthong S,Sriraj W ,et al.Effect of parecoxib onpostoperative pain after lumbar spine surgery: a bicenter, randomized,double-blinded,placebo-controlled trial[ J].Spine,2008,33(2): 132-9.
  • 9Hubbard RC,Naumann TM,Traylor L,et al.Parecoxib sodium has opi-oid-sparing effects in patients undergoing total knee arthroplasty underspinal anaesthesia[J].Br J Anaesth,2003,90(2): 166-72.
  • 10Malan TP,Marsh G,Hakki Sl,et al.Paracoxib sodium,a parenteral cy-clooxygenase 2 selective inhibitors,improves morphine analgesia and isopioid-sparing following total hip arthroplasty [ J ].Anesthesiology ,2003,98(4):950-6.

二级参考文献24

  • 1郝永强,干耀恺,朱振安.塞来昔布对骨科围手术期镇痛的疗效评估[J].中国矫形外科杂志,2007,15(2):131-133. 被引量：28
  • 2Kaye AD,Baluch A,Kaye AJ,et al.Pharmacology of cyclooxygenase-2 inhibitors and preemptive analgesia in acute pain management.Curr Opin Anaesthesiol,2008; 21(4):439-445.
  • 3Reuben SS,Buvanendran A.Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques.J Bone Joint Surg Am,2007; 89(6):1343-1358.
  • 4Bourne MH.Analgesics for orthopedic postoperative pain.Am J Orthop,2004; 33(3):128-135.
  • 5Michael W, Robert F. AO Manual of fracture management internal fixators[ M ]. AO Publishing,2006,1 - 3.
  • 6Australian acute musculoskeletal pain guidelines group. Evidencebased management of acute musculoskeletal pain : executive summary [ M ]. Australian Academic Press Pty. Ltd,2003.
  • 7Stephen B, McMahon A, Martin K. Wall and melzack's textbook of pain 5^th edition[ M ]. London : Elsevier Churchill Livingstone,2005, 362 - 373.
  • 8Biboulet P, Morau D, Aubas P,et al. Postoperative analgesia after total-hip arthroplasty : comparison of intravenous patient-controlled analgesia with morphine and single injection of femoral nerve or psoas compartment block, a prospective, randomized, double-blind study [ J ]. Regional Anesthesia and Pain Medicine ,2004,29 : 102 - 109.
  • 9Fischer HB, Simanski CJ. A procedure-specific systematic review and consensus recommendations for analgesia after total hip replacement [ J ]. Anaesthesia,2005,60 : 1189 - 1202.
  • 10Straube S, Derry S, McQuay H J, et al. Effect of preoperative Cox- Ⅱ- selective NSAIDs (coxibs) on postoperative outcomes : a systematic review of randomized studies[ J]. Acta Anaesthesiol Scand,2005,49: 601 -613.

共引文献46

同被引文献162

引证文献11

二级引证文献38

中国老年学杂志
2013年 第11期

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