摘要
肝细胞癌是临床上最常见的恶性肿瘤之一。大量研究表明,遗传因素在肝细胞癌发病中发挥重要作用。单核苷酸多态性作为第3代遗传标记,是人类基因组中最常见的多态性表现形式,已成为研究肝细胞癌遗传易感性的重要手段。对其深入研究将有利于更好的采取预防、诊断和治疗措施。
Clinically, hepatocellular carcinoma is one of the commonest malignancies. A large number of studies have shown that the genetic factor plays an important role in hepatocellular carcinoma pathogenesis. As the third generation of genetic marker, single nucleotide polymorphism is the commonest polymorphic form in human genome. At present, single nueleotide polymorphism has become an essential means for the study of the genetic susceptibility of hepatoeellular carcinoma. Therefore, the further research into the single nucleotide polymorphism will be highly beneficial to the prevention, diagnosis and treatment of hepatocellular eareinoma.（J Intervent Radiol, 2013, 22： 520-524）
出处
《介入放射学杂志》
CSCD
北大核心
2013年第6期520-524,共5页
Journal of Interventional Radiology
关键词
肝细胞癌
单核苷酸多态性
遗传易感性
hepatocellular carcinoma
single nucleotide polymorphism
genetic susceptibility
