摘要
目的观察尼莫地平注射液对急性大脑中动脉(MCA)M1段闭塞脑梗死的治疗及其对侧枝循环建立的有效性。方法纳入诊断明确MCA Ml段闭塞所致的急性脑梗死患者67例,随机分为尼莫地平治疗组(n=34)和常规治疗对照组(n=33),在治疗前,治疗2w、8w后分别对两组患者进行临床疗效(NIHSS评分及BI评分)及侧枝循环开放程度进行比较。结果治疗2w后治疗组的NIHSS评分及BI评分均优于常规治疗组(15.02±3.07 vs 17.81±3.26,P<0.01;51.57±11.05 vs 45.26±11.21,P=0.03),治疗8w后治疗组的NIHSS评分及BI评分仍优于常规治疗组(7.26±1.97 vs 12.46±2.33,P<0.01;77.35±9.81 vs 66.91±11.54,P<0.01),治疗2w及8w后治疗组比常规治疗组有更好的侧枝循环(RVACA:1.75±0.25 vs 1.21±0.26,P<0.01;1.71±0.27 vs 1.21±0.23,P<0.01)。结论尼莫地平治疗急性大脑中动脉(MCA)M1段闭塞的脑梗死有效且有利于对侧枝循环的建立,从而改善急性大脑中动脉(MCA)M1段闭塞的大面积脑梗死的预后。
Objective To investigate the effects of nimodipine on cerebral infarct and collateral circulation in patients with M1 occlusion.Methods Sixty-seven patients with acute cerebral infarction caused by the occlusion of the M1-segment MCA were included in the study.All the patients were classified as treatment group（n=34） and control group（n=33） according to the random number table.Two groups of patients were evaluated for the clinical efficacy（NIHSS score and BI score） collateral circulation before treatment and two、eight weeks after treatment.Results After 2 weeks treatment,the score of NIHSS and BI of treatment groups were better than control group（15.02±3.07 vs 17.81±3.26,P〈0.01;51.57±11.05 vs 45.26±11.21,P=0.03）.After 8 weeks treatment,the score of NIHSS and BI of treatment groups were also better than control group（7.26±1.97 vs 12.46±2.33,P〈0.01;77.35±9.81 vs 66.91±11.54 P〈0.01）.After 2 and 8weeks treatment,the better collateral circulation were observed in the treatment groups（RVACA：1.75±0.25 vs 1.21±0.26,P〈0.01;1.71±0.27 vs 1.21±0.23,P〈0.01）.Conclusion Nimodipine could effectively improve the nerve function and collateral circulation in cerebral infarct patients with M1 occlusion,Nimodipine also improve the prognosis and disability of massive cerebral infarction in cerebral infarct patients with M1 occlusion.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2013年第5期425-427,共3页
Journal of Apoplexy and Nervous Diseases
关键词
尼莫地平
脑梗死
大脑中动脉
侧枝循环
Nimodipine
Infarction
Middle cerebral artery
Collateral circulation
