摘要
目的:研究ER-β基因多态性与子宫内膜癌组织ER阳性表达的相关性。方法:选择60例子宫内膜癌患者和60例健康对照者,检测两组ER-β基因RsaI和AluI酶切多态性,检测子宫内膜癌组ER阳性表达率。结果:ER-β基因RsaI多态性在EC组和对照组间差异有统计学意义(P<0.05),R等位基因患EC的风险是r等位基因的1.796倍(OR=1.796,95%CI:1.070～3.017);EC组RR基因型癌组织ER阳性表达明显少于Rr、rr基因型(P<0.05)。AluI多态性在EC组和对照组间无统计学差异(P>0.05)。结论:ER-β基因RsaI酶切多态性与子宫内膜癌的发病有相关性,R等位基因可能是EC的遗传易感基因,RR基因型与癌组织ER阳性低表达具有关联性。
Objective： To study the correlation between estrogen receptor - β gene polymorphism and positive expression of estrogen receptor in endometrial cancer. Methods： Sixty patients with endometrial cancer and sixty healthy women were selected; RsaI and Alul polymorphisms of estrogen receptor - β gene in the two groups were detected, the positive expression rate of estrogen receptor in endometrial cancer group was detected. Results： There was statistically significant difference in RsaI polymorphism of estrogen receptor - β gene between endometrial cancer group and control group （ P 〈 0. 05 ）, the risk of endometrial cancer in patients with R allele was 1. 796 times more than that in patients with r allele （ OR = 1. 796, 95% CI： 1. 070 - 3. 017） ; in endometrial cancer group, the positive rate of estrogen receptor in patients with RR genotype was statistically significantly lower than those in patients with Rr genotype and rr genotype （P 〈 0. 05 ） . There was no statistically significant difference in AluI polymorphism between endometrial cancer group and control group （P 〉0.05） . Conclusion：RsaI polymorphism of ER - β gene is correlated with oncogenesis of endometrial cancer, R allele might be one of genetic susceptibility genes of endometrial cancer, there is a correlation between RR genotype and low positive expression of estrogen receptor in endometrial cancer.
出处
《中国妇幼保健》
CAS
北大核心
2013年第17期2772-2774,共3页
Maternal and Child Health Care of China
基金
广西科学研究与技术开发计划项目〔桂科计字(2009)93号〕
右江民族医学院科研项目〔右医院字(2012)21号
(2004)86号〕
