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血清PCT水平预测成人恶性肿瘤粒细胞缺乏性发热伴感染的荟萃分析 被引量：5

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摘要 目的探讨血清降钙素原(PCT)水平预测成人恶性肿瘤粒细胞缺乏性发热(FN)伴感染的临床价值。方法采用计算机检索Cochrane Library、Medline、Embase全文数据库。以Cochrane协作网推荐的诊断试验系统评价质量评价工具标准作为诊断试验质量评价标准,使用Revman5.1、MetaDiSc1.4统计软件进行数据处理。计算敏感度(SEN)、特异度(SPE)、阳性似然比(PLR)、阴性似然比(NLR)、诊断优势比(DOR)及sROC的曲线下面积(AUC)。结果最终纳入10篇合格英文文献。PCT诊断FN伴感染的汇总SEN为0.51(95%CI:0.46～0.56),SPE为0.84(95%CI:0.81～0.87),PLR为3.39(95%CI:2.66～4.32),NLR为0.58(95%CI:0.52～0.65),诊断比值比为6.24(95%CI:4.51～8.65),sROC AUC为0.774 8±0.020 0。结论血清PCT升高诊断成人恶性肿瘤FN伴感染的SEN和诊断准确性均为中等,确诊本病尚需结合患者的临床情况。
作者 苏翔宇 程璐 邓雨霞 陈燕平 李苏宜 刘琳
机构地区 东南大学附属中大医院 江苏省中医院
出处 《山东医药》 CAS 2013年第21期78-80,共3页 Shandong Medical Journal
关键词 恶性肿瘤 发热 粒细胞缺乏性 感染 降钙素原
分类号 R730.43 [医药卫生—肿瘤] R441.3 [医药卫生—诊断学]
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参考文献17

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共引文献4

同被引文献43

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山东医药
2013年 第21期

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