摘要
目的探讨阿昔洛韦联合纳洛酮治疗小儿病毒性脑炎的疗效。方法选取我院从2008年8月至2012年7月所收治的60例小儿病毒性脑炎患者作为临床研究对象,将所有患者随机分为治疗组和对照组,每组各30例。所有患者均进行综合治疗,对照组在综合治疗的基础上加用阿昔洛韦进行治疗,治疗组在综合治疗基础上加用阿昔洛韦联合纳洛酮进行治疗。记录并比较两组患者的疗效与后遗症发生率。结果治疗组患者的有效率为93.3%(28/30),对照组患者的有效率为76.7%(23/30),两组治疗有效率对比,差异有统计学意义(P<0.05)。治疗组患者的后遗症发生率为6.7%(2/30),对照组患者的后遗症发生率为23.3%(7/30),两组后遗症发生率的差异有统计学意义(P<0.05)。结论阿昔洛韦联合纳洛酮治疗小儿病毒性脑炎的疗效和安全性均较佳,值得在临床中推广应用。
Objective To explore the efficacy of acyclovir combined with naloxone in the treatment of children with viral encephalitis. Methods 60 children with viral encephalitis in our hospital from August 2008 to July 2012 were selected as the research object and randomly divided into the treatment group and control group. All cases received the comprehensive treatment. On the basis of the comprehensive treatment, the control group received the acyclovir for treatment, while the treatment group received the acyclovir combined with naloxone for treatment. The clinical curative effect and sequelae incidence were recorded. Results The effective rate was 93.3% in the treatment group, and 76.7% in the control group; the difference of effective rate between two groups was statistically significant （P 〈0.05）. The incidence of sequelae was 6.7% in the treatment group, and 23.3% in the control group; the difference of sequelae between two groups was statistically significant （P 〈0.05）. Conclusions The combination of acyclovir and naloxone in the treatment of children with viral encephalitis has good clinical effect and safety, which is worthy of clinical application.
出处
《临床医学工程》
2013年第6期688-689,共2页
Clinical Medicine & Engineering
