期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

甲状腺髓样癌的诊治进展 被引量：9

下载PDF
导出
摘要 甲状腺癌为头颈部最常见的恶性肿瘤，近年来发病率呈上升的趋势。病理类型主要包括甲状腺乳头状癌、滤泡状癌，髓样癌和未分化型癌。甲状腺髓样癌（medullary thyroid carcinoma，MTC）为低分化癌，属于中度恶性的肿瘤，恶性程度位于甲状腺未分化癌与甲状腺乳头状癌、甲状腺滤泡癌之间，具有早期侵犯区域淋巴结和在病程中易向肺、骨和肝等远处转移的倾向，预后相对较差，虽然只占甲状腺癌总数的3．0％～10．0％，但死亡率达到甲状腺癌的13．4％。MTC发病年龄多在18～25岁，90．0％在50岁之前发病，男女发病率相近，其患病率约为2～20／10万人。
作者 谷琦琦 邱新光
机构地区 郑州大学第一附属医院甲状腺外科
出处 《肿瘤基础与临床》 2013年第3期273-275,共3页 journal of basic and clinical oncology
关键词 甲状腺髓样癌 诊断 治疗
分类号 R736.1 [医药卫生—肿瘤]
  • 相关文献

参考文献18

  • 1Yu GP, Li JC, Branovan D, et al. Thyroid cancer incidence and sur- vival in the national cancer institute surveillance, epidemiology, and end results race/ethnicity groups [ J] . Thyroid, 2010,20 ( 5 ) : 465 - 473.
  • 2Kazaure HS, Roman SA, Sosa JA. Medullary thyroid microcarci- noma: a population-level analysis of 310 patients [ J]. Cancer, 2012,118(3) :620 -627.
  • 3Machens A, Niccoli-Sire P, Hoegel J, et al. Early malignant progres- sion of hereditary medullary thyroid cancer [ J ]. N Engl J Med, 2003,349(16) :1517 - 1525.
  • 4Mulligan LM, Kwok JB, Healey CS, et al. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type2A [ J]. Nature, 1993,363 (6428) :458 - 460.
  • 5Hofstra RM, Landsvater RM, Ceccherini I, et al. A mutation in the RET proto-oncogene associated with muhip|e endocrine neoplasia type2B and sporadic medullary thyroid carcinoma[ J]. Nature, 1994,367 (6461) :375 -276.
  • 6Santaro M, Carlomagno F,Romano A,et al. Activation of RET as a dominant transforming gene by germline mutation of MEN2A and MEN2B[ J]. Science,1995,267(5196) :381 -383.
  • 7Christian A. Molecular pathogenesis of MEN2-associated tumors [ J]. Faro Cancer,2005. d ( 1 ) :3 - 7.
  • 8Kodama Y,Asai N, Kawai K, et al. The RET proto-oncogene : a mo- lecular therapeutic target in thyroid cancer [ J ]. Cancer Sci, 2005, 96(3) :143 - 148.
  • 9de Groot JW, Links TP,Plukker JT, et al. RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors[ J]. Endocr Rev ,2006,27 ( 5 ) :535 - 560.
  • 10Schreiner D, Bennet A, Caron P. Medullary thyroid carcinoma pres- enting as rectangular cell type on fine-needle aspiration [ J ]. Diag- nose Cytopathol,2009,37 ( 3 ) :213 - 216.

二级参考文献13

  • 1MingGao YangYu ShulingLi BenyiXu BaocunSun JingzuLiu.Study of Calcitonin and Calcitonin Gene-related Peptide in Patients with Medullary Thyroid Carcinoma[J].Chinese Journal of Clinical Oncology,2005,2(1):500-504. 被引量：6
  • 2李勇,张湘茹,孙燕.多靶点抗肿瘤新药:ZD6474[J].癌症进展,2006,4(3):206-210. 被引量：19
  • 3于洋,高明,杨力珍,徐文贵,陈秋松.PET/CT在甲状腺癌中的应用[J].现代肿瘤医学,2006,14(12):1509-1512. 被引量：5
  • 4王利,刘文玉,周桂芝.癌胚抗原在诊断肠癌及其他肿瘤中的应用[J].白求恩军医学院学报,2007,5(2):115-116. 被引量：4
  • 5Colombo P, Locatelli F, Travaglini P. Useful and limits of the bio- chemical markers for the diagnosis of thyroid carcinoma [ J ]. Ann Ital Chir, 2006, 77(3): 209-214.
  • 6Sanso GE, Domene HM, Garcia R. Very early detection of RET proto- oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: presence of C - cell malignant disease in asymptomatic carriers [ J ]. Cancer, 2002, 94 (2) : 323 - 330.
  • 7Alaedeen DI, Khiyami A, McHenry CR. Fine - needle aspiration bi- opsy specimen with a predominance of Hurthle cells : a dilemma in the management of nodular thyroid disease [ J ]. Surgery, 2005, 138 (4) : 650 - 656.
  • 8Houvras Y. Completing the Arc : Targeted Inhibition of RET in Medul- lary Thyroid Cancer[J]. J Clin Oncol, 2012, 30(2) : 200 -202.
  • 9Iacobone M, Niccoli - Sire P, Sebag F, et al. Can sporadic medullary thyroid carcinoma be biochemically predicted? Prospective analysis of 66 operated patients with elevated serum calcitonin levels [ J ]. World J Surg, 2002, 26(8): 886-890.
  • 10Costante G, Meringolo D, Durante C, et al. Predictive value of ser- um calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nod- ules[J]. J Clin Endocrinol Metab, 2007, 92(2) : 450-455.

共引文献26

同被引文献54

引证文献9

二级引证文献62

肿瘤基础与临床
2013年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部