摘要
有关炎症与肿瘤相互关系的研究已成为目前肿瘤研究的热点之一。髓样细胞表达触发受体-1(TREM-1)作为一种免疫球蛋白超家族激活型受体,在炎症反应发生、级联放大中具有重要作用,可影响肿瘤微环境中各种相关细胞因子(如IL-8、MCP-1、TNF-α)水平,通过损伤、抑制修复等机制参与肿瘤发生、浸润和转移等病理性过程,影响患者预后。本文主要就TREM-1在肿瘤方面的相关研究进展进行综述。
Abstract：The relationship between inflammation and cancer research has become one of the hottest spots of cancer re cently. Triggering receptor expressed on myeloid cells-1 （ TREM- 1 ） has been identified as a stimulate receptor of immu noglobulin superfamily, which plays an important role in the progress of pro-inflammation or amplification of inflammato- ry responses, it can influence the pathological reaction process like tumor occurrence, invasion and metastasis together with various inflammatory cells and cytokines recruited to the tumor microenvironment through different mechanisms, such as damage, repair suppression,and so on. In this paper, we will review the role of TREM-1 from different aspects associated with tumor.
出处
《医学与哲学（B）》
2013年第5期60-62,共3页
Medicine & Philosophy(B)
关键词
髓样细胞表达触发受体-1
炎症反应
肿瘤微环境
转移
预后
triggering receptors expressed on myeloid cells- 1, inflammatory response, tumor microenvironment, metasta-sis, prognosis
