摘要
目的 采用小白鼠缺氧模型对 β 内啡肽 (β EP)在小白鼠缺氧中的作用、注射纳洛酮(NLX)对缺氧小白鼠呼吸抑制的反转及对低氧存活时间 (HST)的影响进行研究 ,以探讨新生儿窒息时临床使用NLX的指针及时机。方法 小白鼠分成 5组 ,第 1、2组进行耗氧试验 ,第 3～ 5组进行HST试验。结果 小白鼠经缺氧处理后耗氧时间比常氧状态下的耗氧时间延长 ,β EP含量也明显升高 ,而注射NLX后 ,缺氧处理后出现的耗氧时间延长消失 ;经缺氧处理后注射NLX小鼠的HST比注射生理盐水小鼠的HST明显缩短。结论 NLX能阻断缺氧后释放的 β EP ,使呼吸抑制反转 ,但使小鼠的HST缩短 ,说明新生儿窒息时应纠正 β EP释放所引起的呼吸抑制、低体温等不良影响 ,但使用NLX时需清除呼吸道保证给氧 ,否则 ,对新生儿有不利影响。
Objective In order to determine the scale and time of naloxone (NLX) treatment in neonatal asphyxia,the study was carried out using mice hypoxic models,about the effects of β-endorphin (β-EP),the reverse of respiratory depression and the change of hypoxic survival time (HST) in mice injected with NLX in the hypoxic condition.Methods The mice were divided into 5 groups.The first two groups received oxygen exhausting test,while the other three groups tested hypoxic survival time.Results Oxygen exhausting time of mice was significantly longer and the levels of β-EP were significantly higher under hypoxic condition than under sham condition,but the prolonged oxygen exhausting time of mice under the hypoxic condition disappeared after injection of NLX;there was a significant decrease in HST in the NLX-treated mice compared to those in the saline-treated mice.Conclusion NLX can block the effect of β-EP released,reverse the respiratory depression,and shorten the HST under hypoxic condition.The results suggested that the respiratory depression and lower body temperature caused by β-EP release should be corrected in neonatal asphyxia.NLX can be used in neonatal asphyxia on condition that the respiratory trace has been cleaned.Otherwise,it might be adverse to the newborn.
出处
《江苏医药》
CSCD
2000年第8期607-608,共2页
Jiangsu Medical Journal
关键词
呼吸抑制
纳洛酮
低氧存活时间
新生儿窒息
Respiratory depression β-endorphin Naloxone Hypoxic survival time
