摘要
目的 :观察乙酰半胱氨酸注射液 (NAC)治疗慢性重型肝炎的疗效。方法 :收治慢性重型肝炎 88例 ,随机分为治疗组与对照组。对照组 4 4例采用前列腺素E1(PGE1) ,0 .1～ 0 .2mg/d加入 5%葡萄糖注射液中静脉滴注。治疗组 4 4例用 3 %NAC 2 50ml静脉滴注 ,每日一次。疗程一般均为一个月。结果 :治疗组显效为 63 .6% ,有效为1 1 .3 % ,对照组显效为 4 5.4 % ,有效 2 2 .7% ,两组显效率比较有显著性差异 (P <0 .0 5)。治疗组血清胆红素 ( μmol/L)从 3 3 7± 3 0下降至 69± 3 1 ,对照组从 2 74± 3 1下降至 84± 2 9,两组间有显著性差异 (P <0 .0 5)。不良反应低于对照组。结论 :静脉应用乙酰半胱氨酸治疗慢性重型肝炎是安全而有效的。
OBJECTIVE:To see whether intravenous acetylcysteine would improve outcome in patients with chronic liver failure(CLF).METHOD:The investigation was carried out among 88 case of CLF who were divided at random into two group:acetylcysteine(treated group) and PGE 1(control group).Dosages of one vial(3% acetylcysteine 250ml) for treated group and one vial(PGE 1 0.1～0.2mg in 5% glucose 500ml) for control group were given intravenously to each subject qd for 1 month,respectively.RESULTS:The rate of pronounced valid was significantly higher in the treeated group than the controls group[63.6%(28/44) υ 45.4%(20/44),P<0.05].The effective rates of treated group and control group were 11.4%(5/44) and 22.7%(10/44) respectively.In the treated group,the reduced values of serum bilirubin(μmol/L) were significantly lower than the control one(from 337±30 to 69±31 υ 274±31 to 84±29,P<0.05) Side effects of the treated group were lower than those of the control one.CONCLUSION:Intraven ous acetylcysteine is safe and effective in patients with CLF.
出处
《中国现代应用药学》
CAS
CSCD
2000年第4期327-329,共3页
Chinese Journal of Modern Applied Pharmacy
