摘要
目的:探讨利培酮、齐拉西酮和阿立哌唑对精神分裂症患者认知功能的影响。方法:98例急性期精神分裂症患者分为利培酮组32例,齐拉西酮组35例和阿立哌唑组31例,分别予利培酮、齐拉西酮和阿立哌唑治疗8周。以重复性成套神经心理状态测验(RBANS)评价患者认知社会功能变化。结果:利培酮组RBANS注意力(F=0.26)、即刻记忆(F=41.62)和视觉空间结构(F=3.09)变化差异有统计学意义(P均=0.00),但语言(F=17.65)和延迟记忆(F=0.17)变化差异无统计学意义(P均>0.05)。阿立哌唑组RBANS即刻记忆(F=50.66)和语言(F=17.53)变化差异有统计学意义(P均=0.00)。齐拉西酮组在即刻记忆(F=51.62)、视觉空间结构(F=63.12)变化差异有统计学意义(P均=0.00)。结论:利培酮、阿立哌唑、齐拉西酮虽同属非典型抗精神病药,但对认知功能的影响不尽相同。
Objective：To compare the drug effect of risperidone,ziprasidone,aripiprazole in improving cognitive function of schizophrenia patients. Method：98 schizophrenia patients in their acute episode were randomedly divided into three groups named as risperidone group（ n = 32） ,ziprasidone group（ n = 35） and aripiprazole group（ n = 31） and they were treated for eight weeks. All the subjects were assessed their cognitive function with repeatable battery for the assessment of neuropsychological status （ RBANS） at the baseline and 2 months later. Results：It showed a significant difference on RBANS attention（ F = 0. 26） ,immediate memory （ F =41.62） and visual-spatial structural changes（ F =3.09） in risperidone group（ all P =0.00） while it showed no difference on language（ F = 17. 65,P = 0. 08） and delayed memory（ F = 0. 17,P = 0. 46） . It showed a significant difference on RBANS immediate memory（ F = 50. 66） and language（ F = 17. 53） in aripiprazole group （ all P = 0. 00） . It showed a significant difference on RBANS immediate memory（ F = 51. 62） and visual-spatial structural changes（ F = 63. 12） in ziprasidone group（ all P = 0. 00） . Conclusion：Risperidone,aripiprazole and ziprasidone all belong to unatypical antipsychotic drugs but their impact on cognitive function are not the same.
出处
《临床精神医学杂志》
2013年第3期198-200,共3页
Journal of Clinical Psychiatry
