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肾阳虚型不孕女性行宫腔内人工授精术中补加复方玄驹胶囊的临床疗效 被引量:7

Xuanju Compound capsules improve the success rate of intrauterine insemination in infertile women with kidney-yang deficiency
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摘要 目的宫腔内人工授精(intrauterine insemination,IUI)的成功率受诸多因素影响,如患者类型、术中用药等。文中观察肾阳虚型不孕女性行IUI术中补加复方玄驹胶囊的临床疗效。方法将入选的肾阳虚型不孕患者随机分为观察组24例和对照组27例。对照组采用本中心的常规IUI方案,观察组在常规IUI方案的基础上,根据月经周期口服复方玄驹胶囊。观察2组患者的临床症状、血清激素水平、卵泡发育情况、内膜厚度和妊娠结局。临床症状主要以疗效指数为评判标准,疗效指数≥95%为痊愈,70%≤疗效指数<95%为显效,30%≤疗效指数<70%为有效,疗效指数<30%为无效。结果①复方玄驹胶囊对肾阳虚临床症状的治愈率达50.0%,总有效率为83.3%;对照组治愈率为3.7%,总有效率为22.2%,2组比较差异有统计学意义(P<0.01)。②注射绒毛膜促性腺激素(human chorionic gonadotropin,hCG)、日血清黄体生成素(lute-inizing hormone,LH)、雌二醇和孕酮水平2组比较差异无统计学意义。③授精日成熟卵泡个数、卵泡直径、子宫内膜厚度2组相比差异无统计学意义,但观察组子宫内膜厚度优于对照组。④2组妊娠结局比较:观察组与对照组的临床妊娠率为25.0%vs 14.8%,差异无统计学意义。结论对实施IUI治疗的肾阳虚型不孕患者,根据月经周期的阴阳转化节律补加复方玄驹胶囊,可明显缓解临床症状,增加子宫内膜厚度,从而达到助孕目的。 ObjectiveThe success rate of intrauterine insemination (IUI) is influenced by various factors, such as patient type and intraoperative medication. We studied the clinical effects of Xuanju Compound capsules on infertile women with kidney-yang deficiency undergoing IUI.MethodsWe randomly allocated 51 infertile women with kidney-yang deficiency to a control group (n=27) and an experimental group (n=24). Both underwent conventional IUI, while the latter received oral medication of Xuanju Compound capsules in addition according to their menstrual cycles. We compared the clinical symptoms, serum hormone levels, follicular development, endometrial thickness and pregnancy outcomes between the two groups of patients. The evaluation criteria for the clinical symptoms were based on the therapeutic index (TI) as follows, cured: TI ≥95%, obviously effective: TI ≤70 to 〈95%, effective: TI ≤30 to 〈70%, ineffective: TI 〈30%.ResultsThe cure rate and total effectiveness rate were 50% and 83.3% in the experimental group, significantly higher than 3.7% and 22.2% in the controls (P〈0.01). There were no significant differences in the levels of LH, E2 and P on the day of HCG injection, nor in the number of mature follicles, follicle diameter and endometrial thickness on the day of artificial insemination between the two groups. The pregnancy rate was 25% in the experimental group, with no significant difference from 14.8% in the control.ConclusionAccording to the menstrual cycle and the rhythm of yin and yang, administration of Xuanju Compound capsules to infertile women with kidney-yang deficiency can relieve their clinical symptoms, increase endometrial thickness and add to the success rate of fertilization.
出处 《医学研究生学报》 CAS 北大核心 2013年第6期589-591,共3页 Journal of Medical Postgraduates
基金 国家自然科学基金(81070480)
关键词 复方玄驹胶囊 肾阳虚 宫腔内人工授精 Xuanju Compound capsule Kidney-yang deficiency Intrauterine insemination
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