摘要
目的探讨曲安奈德玻璃体腔注射（intravitreal triamcinolone acetonide，IVTA）治疗葡萄膜炎黄斑囊样水肿的疗效和并发症情况。方法回顾性临床自身对照研究。对2008年10月至2010年10月在大连市第三人民医院眼科确诊为葡萄膜炎黄斑囊样水肿的患者10例16只眼，均进行曲安奈德玻璃体腔注射治疗。术后观察视力、眼压、黄斑中心凹厚度、晶状体透明度以及葡萄膜炎复发等。采用治疗前后均数比较f检验。结果术后OCT显示16只眼（100％）黄斑囊样水肿均消失，黄斑中心凹厚度减低。术前黄斑区神经上皮层厚度为（510．63±99．06）μm，术后为（170．25±24．54）μm，两者相比差异有统计学意义（t=11．282，P=0．001）。术后视力均有大幅提高，术后出现继发性青光眼4例5只眼（31．25％），并发性白内障3例4只眼（25％）。随访18个月后葡萄膜炎黄斑囊样水肿复发1例（6．25％）。结论曲安奈德玻璃体腔注射是治疗葡萄膜炎黄斑囊样水肿的有效方法。其并发症有眼压升高和并发性白内障。
Objective To investigate the effects and complications of treatment for uveitis with cystoid macular edema by intravitreal triamcinolone acetonide （IVTA）. Methods It was a retrospec- tive case series study. Ten cases （16 eyes） were performed with IVTA. Patients suffering from uve- itis with cystoid macular edema were selected for the study from October 2008 to October 2010 treated in our hospital. The visual acuity, intraocular pressure, foveal thickness, transparency of lens and recurrence of uveitis etc. were examined postoperatively, t test was used for statistics analysis. Results A relief of cystoid macular edema was observed in 16 eyes （100%） after operations. The preoperative mean thickness of foveal was （510,63±99.060）μm while postoperative mean was （170.25±24.541）μm, which was a significant difference （t =11.282, P =0.001）. The visual acuity of all pa- tients was improved obviously after operations. Five eyes （31.25%） underwent high intraocular pres- sure, and four eyes （25%） manifested cataract. One eye （6.25%） underwent recurrent uveitis 18 months after the initial treatment. Conclusions Intravitreal triamcinolone acetonide is an effective treatment for uveitis with cystoid macular edema. Complications include high intraocular pressure af- ter IVTA and progression of cataract.
出处
《中国实用眼科杂志》
CSCD
北大核心
2013年第6期676-679,共4页
Chinese Journal of Practical Ophthalmology
关键词
葡萄膜炎
黄斑水肿
囊样
曲安奈德
Uveitis
Macular edema
Cystoid
Triamcinolone acetonide
