摘要
将海藻酸钠(SA)和β-环糊精(β-CD)共混制备了复合水凝胶,并讨论了交联剂浓度、原料配比对水凝胶溶胀性能的影响。结果表明,当两者的共混比例为1∶2、w(交联剂)为6%、交联时间为1h时,水凝胶的溶胀性能较好。水凝胶在pH=1.2时的溶胀率仅为1.2,而在pH=7.4时的溶胀率达到14.2,具有良好的pH敏感性。以牛血清蛋白(BSA)为模型药物,研究了β-CD/SA水凝胶作为药物载体对BSA的负载及释放性能,结果表明:在模拟胃液中的累计释放量较小(21.5%),且释放速率较慢;在模拟肠液中的累计释放量为70.2%,具有良好的pH敏感控制释放性能。
The sodium alginate （SA） and fl-cyclodextrin （fl-CD） were mixed to prepare hydrogel. The effect of the concentration of crosslinke, and the ratio of materials ml the swelling behaviors of hydrogels had been studied. The results showed that when tire mass ratio of two materials, eoncentration of erosslinker and tire erosslinking time were I ： 2, 6, lh separately, the swelling behavior of bydrogels was best. It was found that the swelling ratio （SR） was influen＇ed by pit values. The SR of hydrogel was 1.2 in tire solution of pH = 1.2, while the SR was 14. 2 at pH =7.4. Bovine serttm albumin （ BSA ） was selected as model drug, the drug release behaviors under different pH values were in- vesligated. Test showed that the accumulated amount of drug release was only 21.5% in simulated gastric fluid, while it was 70. 2e in simulated intestinal fluid.
出处
《精细与专用化学品》
CAS
2013年第6期37-41,共5页
Fine and Specialty Chemicals
基金
江苏省新型环保重点实验室开放课题基金资助(AE201115)
关键词
海藻酸钠
Β-环糊精
水凝胶
溶胀性
控制释放
sodium alginate
β-cyclodextrin
hydrogel
swelling behavior
controlled release
