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血浆心型脂肪酸结合蛋白水平在急性冠脉综合征患者PCI术后心肌损伤及预后的预测价值 被引量：7

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摘要 目的探讨急性冠脉综合征(ACS)患者经皮冠脉介入治疗术(PCI)前后血浆心型脂肪酸结合蛋白(H-FABP)水平及对术后心肌损伤和预后的预测价值。方法留取169例ACS患者胸痛症状发作6～10 h的PCI术前血标本,酶联免疫法测定H-FABP,入选患者按H-FABP(<11.82 g/L和≥11.82 g/L)浓度进行分组。记录Gensini冠脉病变评分,并观察ACS患者PCI术后30 d心源性死亡和主要心脏不良事件(MACE)发生率。结果 H-FABP水平与冠脉病变支数和Gensini冠脉病变评分均呈正相关(=0.754、0.842,<0.05);2组术后30 d的MACE发生率为11.49%和4.88%(>0.05)。多变量逐步Logistic回归分析表明,H-FABP、UA和左主干病变是ACS患者PCI后30d发生MACE的危险因素(均<0.05)。结论 H-FABP水平变化有助于早期识别PCI术后心肌损伤,PCI术前H-FABP水平升高是ACS患者PCI术后再发MACE的独立危险因素。
作者 俞燕 章秀清 王卫忠
机构地区 浙江省人民医院 杭州小河湖墅地段卫生服务中心
出处 《现代实用医学》 2013年第5期512-513,599,共3页 Modern Practical Medicine
基金 浙江省医学重点学科基金(07-010)
关键词 心型脂肪酸结合蛋白 经皮冠状动脉介入治疗 肌钙蛋白T
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献8

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共引文献7453

同被引文献78

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引证文献7

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现代实用医学
2013年 第5期

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