摘要
目的评价依托必利、莫沙必利、多潘立酮联用黛力新治疗功能性消化不良(FD)的疗效。方法 130例确诊的FD患者随机分为3组,依托必利治疗组50例,依托必利50 mg,tid,黛力新1片,bid;莫沙必利对照组(Ⅰ组)40例,莫沙必利5 mg,tid,黛力新1片,bid;多潘立酮对照组(Ⅱ组)40例,多潘立酮10 mg,tid,黛力新1片,bid。疗程均为4周。观察患者服药前及服药1周、4周后嗳气、烧心、上腹部饱胀等症状的消失情况并做对比分析。结果治疗1周后嗳气、烧心和上腹部饱胀症状的消失率,治疗组分别为60%、56%,对照Ⅰ组为30%、35%,对照Ⅱ组为25%、25%。治疗组与各对照组之间的差异比较均有显著性(P<0.05)。治疗4周后治疗组的嗳气、烧心和上腹部饱胀症状的消失率为88%、84%,对照Ⅰ组为40%、45%,对照Ⅱ组为25%、30%,治疗组与各对照组之间的差异比较均有非常显著性(P<0.01)。结论依托必利联用黛力新改善FD患者嗳气、烧心、上腹部饱胀症状的效果最满意,可以作为治疗FD患者的首选药物。
Objective Functional dyspepsia （FD） is a highly prevalent disease, psychological factors may be closely correlated with the occurrence of FD, but there are only few published reports on the comparative study on the treatment of FD by the gastrointestinal motility drugs with deanxit in China. Aims ： To evaluate the curative effects of hopride, mosapride, domperidone with deanxit for the treatment of FD. Methods 65 cases of patients diagnosed with FD were divided into three groups ： Itopride treatment group of 25 cases was treated with itopride 50 mg rid and deanxit 2 pills qd, mosapride control group （ group Ⅰ ） of 20 cases was treated with mosapride 5 mg tid and deanxit 2 pills qd, and domperidone control group （ group Ⅱ） of 20 cases was treated with domperidone 10 mg tid and deanxit pills qd. The course of treatment all lasted 4 weeks. The symptoms of the patients that disappeard after the drugs taken were observed and comparatively analyzed. Results After 1-week treatment, the rates of the symptoms that disappeared such as belching, pre- and- postprandial bloating were respectively 60% and 56% in treatment group, compared with 35 % and 40% in control group Ⅰ ,30% and 30% in control group Ⅱ ,while significant different was observed between treatment group and the two control groups （ P 〈 0.05 ）. After 4- weeks treatment, the rates of the symptoms that disappeared were respectively 88 % and 80% in treatment group, compared with 45% and 45% in control group Ⅰ,30% and 35% in control group Ⅱ, while significant different was observed between treatment group and the two control groups（ P 〈 O. O1 ）. Conclusion The effect of combined treatment of itopride and deanxit in relieving the belching and pre- and-postprandial bloating symptoms is satisfactory, and it is the preferred alternative for FD currently.
出处
《临床消化病杂志》
2013年第3期138-140,共3页
Chinese Journal of Clinical Gastroenterology
