摘要
目的 观察皮下注射亚甲蓝、罗哌卡因复合液用于会阴部术后镇痛的EC95并探讨最佳临床使用浓度。办法选取骶麻效果确切的180例混合痔、肛瘘、肛裂患者，术毕沿切缘皮下环形注射亚甲蓝、罗哌卡因复合液。前30倒患者设定为Ⅰ组，按序贯试验法确定亚甲蓝的浓度，起始浓度为0．1％，相邻浓度比值为1．5，直至实验结束，用概率单位回归法计算EC95。后150例患者随机分为Ⅱ，Ⅲ，Ⅳ组，用作EC95，及再上升两个浓度梯度间镇痛效果及副作用比较。结果亚甲蓝用于会阴部术后镇痛的EC95为0．105％，95％的可信区间为0．08％-0．137％．Ⅱ，Ⅲ，Ⅳ组均能达到即时和长效有效镇痛，平均VAS评分低于5分，Ⅱ组评分高于Ⅲ，Ⅳ组（P〈0．05）。Ⅳ组术后局部硬结、局部感觉异常的发生率高于前两组。结论亚甲蓝的EC95为0．105％，亚甲蓝、罗哌卡因混合液皮下环形注射用于会阴部术后具有良好的即时和长效镇痛效果。亚甲蓝的稚荐使用浓度为0．15％．
Objective To research EC95 of the subcutaneous injection of methylene blue,ropivacaine compound fluid preparation in postoperative analgesia of perineum, and to explore the best concentration for clinical use. Methods One hundred and eighty cases of mixed hemorrhoid,anal fistula and anal fissure patients with exactly effect of sacral hemp were chosen,methylene blue and ropivacaine com- pound fluid was injected along the cutting edge subcutaneous ring after surgery. First 30 patients were set to group I according to the sequen- tial test method to determine the concentration of methylene blue. Initial concentration was 0.1% , and the adjacent concentration ratio was 1. 5 until the end of the experiment. Prnbability unit regTession method was used to calculate EC95. The latter 150 patients were randomly divided into group Ⅱ , Ⅲ anti Ⅳ with two concentration gradient interval, and EC95 , contrasting analgesia eftect and side effects among the groups were measured. Results Methylene blue fnr postnperative analgesia of perineum EC95 was 0. 105% ,and 95% confidence interval was 0.08%-0. 137%. Group Ⅱ ,Ⅲ, Ⅳean achieve the immediate and hmg-lerm effective analgesia, average VAS score was below 5 points, the score of group Ⅱ was higher than group Ⅲ, Ⅳ（P〈 0.05） In group IV there was local callosity postoperatively,and the local feel abnormal rate was higher than the previous two groups. Conclusion Methylene blue EC95 is 0. 105%. Methylene blue and ropivacaine bromide mixture subcu- taneous ring injectiou used in perineum postoperative has good immediate and long-term analgesic effect. The recommended concentration of methylene blue is 0.15%.
出处
《潍坊医学院学报》
2013年第3期215-216,共2页
Acta Academiae Medicinae Weifang
关键词
皮下注射
会阴部手术
亚甲蓝
镇痛
Subcutaneous injection
Perineum surgery
Methylene hlue
Analgesia
