摘要
目的:研究探索分化抑制因子(inhibitors of differentiation,Id)在多种肺癌细胞中的表达及意义。方法:随机选取北京大学深圳医院2009年1月至2010年12月30例肺癌及同样例数正常组织,采取免疫组化s-p法检测Id1在不同组织的表达状况。结果:在多种肺癌组织中,Id_1均表现为过度表达,与正常肺组织表达情况比较差异有统计学意义(P<0.01);在不同病理表现(腺癌、鳞癌、腺鳞癌)、性别、及年龄中表达差异无统计学意义(P>0.05);在肺癌淋巴结转移组中Id_1表达明显高于无淋巴结转移组(P<0.05)。结论:Id_1基因作为癌基因在肺癌的发生发展中发挥作用,与肺癌淋巴结转移密切相关,可能为多种肺癌诊断及预后的标志物。
Objective：To investigate the expression and clinieal significance of inhibitor of differentiation l （Id1 ） in various types of lung cancer. Methods： hnmunohistochemical s-p assay was employed to detect Id1 expression in various lung cancer and normal lung tissues obtained from 30 patients admitted to Affiliated Shenzhcn Hospital of Peking University between January 2009 and December 2010. Results： Compared with normal lung tissues, the lung cancer tissues yielded a significantly augmented Id1 expression （P 〈 0.01 ）. The diffcrence in Id1 expression in patients with various types of lung cancer （adenoma, squamous cell carcinoma or adenosquamous carcinoma） , either sex and different age groups was unremarkable （ all P 〉 0.05 ）. Patients with lymph node metastasis had a significantly augmented Id1 expression than those not （P 〈 0.05 ）. Conclusion： The Id1 gene may play a pivotal role in the pathogenesis of lung cancer as an oncogene and is closely correlated lymph node metastasis, suggesting that Id1 might be regarded as new marker for the diagnosis and prognosis of lung cancer.
出处
《广州医学院学报》
2013年第2期67-69,共3页
Academic Journal of Guangzhou Medical College
关键词
Id1蛋白
肺癌
表达
Id1 protein
lung cancer
expression
