摘要
目的:探讨CVE方案结合局部治疗对儿童眼内期视网膜母细胞瘤的疗效。方法:选取2008年6月-2011年6月我科收治的眼内期视网膜母细胞瘤患儿,对其临床数据进行分析。采用CVE方案结合局部治疗的方法治疗。结果:共31例(40只患眼),其中单侧患儿22例,双侧患儿9例,平均年龄22.8个月,平均随访27.8个月。采用Reese-Ellsworth分级法,17只眼为Ⅰ～Ⅲ级,治疗后16只眼(94.1%)持续缓解,1只眼(5.9%)仍发生进展;23只眼为Ⅳ～Ⅴ级,治疗后9只眼(39.1%)持续缓解,14只眼(60.9%)出现肿瘤复发或新发病灶。所有病例都能耐受化疗,仅4例(12.9%)发生轻度肝功能损害。结论:CVE方案与局部治疗相结合,可以对眼内期视网膜母细胞瘤进行有效的治疗,降低外照射放疗及眼球摘除手术的应用率,提高患儿生存质量。
OBJECTIVE：To explore therapeutic efficacy of CVE combined with local treatments for children with intraocular retinoblastoma. METHODS：Children with intraocular retinoblastoma admitted in our department during Jun. 2008-Jun. 2011 were enrolled in the study,and clinical data were analyzed. RESULTS：There were 40 eyes of 31 children,22 children were unilateral disease and 9 children were bilateral disease. Mean age of the children was 22.8 months,and mean follow-up period was 27.8 months. According to Reese-Ellsworth classification,17 eyes wereⅠ-Ⅲ,16 eyes（94.1%）were in complete remission,1 eye（5.9%）pro- gressed;23 eyes were Ⅳ-Ⅴ,9 eyes（39.1%）were in complete remission,and other 14 eyes（60.9%）suffered from tumor reoccurrence or new disease. All children could tolerate chemotherapy,only 4 children（12.9%）occurred mild hepatotoxicity. CONCLUSIONS：The combination of CVE and local treatment is effective for intraocular retinoblastoma,which can eliminate the application rate of external beam radiotherapy or enucleation and improve the quality of life in retinoblastoma children.
出处
《中国药房》
CAS
CSCD
2013年第26期2444-2446,共3页
China Pharmacy
