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帕罗西汀联合中药治疗抑郁症的疗效及安全性评估 被引量:6

The Safety and Efficacy Evaluation of Traditional Chinese Medicine For the Auxiliary Treatment of Depression
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摘要 [目的]观察中药辅助治疗抑郁症的临床疗效,并评估其安全性。[方法]将238例抑郁症患者随机分成两组,治疗组用帕罗西汀(葛兰素史克公司生产,商品名:赛乐特),起始剂量20mg.d-1,可按病情需要调整剂量,最大剂量为50 mg.d-1,根据中医辨证,联合使用中药治疗。对照组单用帕罗西汀,使用方法同治疗组,疗程6周。于治疗前、治疗第1、2、4、6周末分别采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、副反应量表(TESS)评定疗效及安全性。[结果]至研究终点,治疗组和对照组的有效率分别为81.67%、64.40%;治疗组与对照组HAMD、HAMA评分均低于治疗前,治疗组评分低于对照组,差异有统计学意义(P<0.05)。治疗组不良反应发生率12.50%,低于对照组29.66%,差异有统计学意义(P<0.05)。[结论]中药辅助治疗抑郁症有一定的临床疗效,可减少抗抑郁药的使用剂量,并减少不良反应的发生。 [Objective] To evaluate the efficacy and safety of Traditional Chinese Medicine(TCM)in treatment of depressive disorder.[Methods] The randomized controlled trial which was given Decotion combined with paroxetine(brand name seroxat) was conducted in 120 patients of the study group,and 118 patients of the control group were given paroxetine only.Paroxetine was used from 20mg to 50mg every day for all patients depending on clinical need.A treatment was six weeks.The clinical efficacy,adverse reaction was evaluated with scores by Hamilton Depression Scale,Hamilton Anxiety Scale,Treatment Emergent Symptoms Scale before and first,2nd,4th,6th weeks after treatment,respectively.[Results] In the end,the effective rate in the study group was 81.67% and 64.40% in the control group;the scores of HAMD and HAMA were significantly decreased in both groups after treatment(P&lt;0.05) and the scores of HAMD and HAMA were significantly lower in the study group than that in the control group.The study group adverse reaction rate was 12.50% lower than those of the control group 29.66%,the difference was significant.[Conclusion] The efficacy of TCM combined paroxetine is better than paroxetine,and can decrease the incidence of adverse reaction rate.
出处 《浙江中医药大学学报》 CAS 2013年第6期697-700,共4页 Journal of Zhejiang Chinese Medical University
基金 浙江省中医药科技计划(2007GA031) 湖州市科技计划项目(新农村建设)(2007YS13)~~
关键词 抑郁症 中药治疗 帕罗西汀 depression Chinese medicine treatment Paroxetine
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