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序贯疗法与标准四联疗法根除HP的疗效比较

Efficacy Comparison of Sequential Therapy and Standard Quadruple Therapy for Eradication of HP
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摘要 目的幽门螺杆菌(Helicobacter pylori,Hp)耐药率逐渐增加,标准四联疗法根除率下降,需要新的治疗方法。方法 78例患者随机分成治疗组和对照组,治疗组(序贯疗法)方案为前5d雷贝拉唑+阿莫西林,后5d雷贝拉唑+左氧氟沙星+替硝唑,疗程共10d。对照组(标准四联疗法)方案为雷贝拉唑+阿莫西林+克拉霉素+果胶铋,疗程共10d。所有患者停药4周后复查14C尿素呼气试验检测HP根除率。结果序贯治疗(治疗组)Hp根除率84.6%(33/39),四联疗法(对照组)Hp根除率为71.8%(28/39),两组间比较差异有统计学意义(P<0.05)。结论 10d序贯疗法Hp根除率优于标准四联疗法。 Objective Antibiotics resistance of Helicobacter pylori (HP) increased, eradication rate of conventional quadruple therapy decreased gradually.New fist-line treatments for Hp eradication need to be developed.Methods We have prospectively evaluated 10-day sequential therapy versus conventional quadruple therapy in HP eradication rate.Seventy-eight patients with HP infection were prospectively randomized to receive 5 days of rabeprazole and amoxicillin followed 5 dqys of rabeprazole, Levofloxacin and Tinidazole(sequential-therapy) or 10-days rabeprazole, amoxicillin, clarithromycin and bismuth(conventional quadruple therapy).HP was detected by the 14C-urea breath test at the fourth week post-treatment.Results HP eradication rates were 84.6% in the sequential therapy group and 71.8% in the conventional quadruple therapy group.The difference between the sequential therapy group and the conventional quadruple therapy group was significant (P〈0.05) .Conclusions 10-day sequential therapy yielded a higher HP eradication rate than 10-day conventional quadruple therapy.
出处 《中国医药指南》 2013年第14期438-439,共2页 Guide of China Medicine
关键词 序贯疗法 幽门螺杆菌 四联疗法 Sequential therapy Helicobacter pylori Quadruple therapy
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参考文献6

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二级参考文献22

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