摘要
目的:探讨血清鳞状上皮细胞癌抗原(SCCAg)在宫颈癌诊断、疗效评估等方面的应用价值。方法:本研究选择了2011年9月—2012年3月天津市中心妇产科医院妇瘤科的住院患者145例,全部为可疑宫颈癌患者,经病理组织学确诊分为宫颈上皮内瘤变(CIN)Ⅲ组55例和宫颈癌组90例。采用化学发光的方法检测患者术前血清SCCAg的浓度,结合临床资料和病理组织学诊断,分析评价SCCAg与临床分期、组织分化程度的相关性及其对宫颈癌的诊断价值,通过术前与术后SCCAg检测值的比较评价其在疗效评估方面的价值。结果:血清SCCAg浓度在CIN组和宫颈癌组中的差异有统计学意义(P=0.000),治疗后SCCAg水平较治疗前显著下降(P=0.000);按国际妇产科联盟(FIGO)分期分组讨论,随疾病的进展,临床分期的加重,SCCAg的数值增高,阳性率亦增高,两者具有正相关性;SCCAg在可疑宫颈癌人群的检测敏感度为71.1%,特异度72.7%,准确度71.7%,阴性预测值60.6%,阳性预测值81.0%;CINⅢ的检测阳性率为27.3%,宫颈鳞癌Ⅰ期患者的检测阳性率为66.7%。结论:SCCAg对宫颈鳞状上皮细胞癌具有诊断价值,对疗效监测及预后判断也有重要临床意义,但在早期诊断方面仍有局限性,与宫颈癌的病理类型、临床分期有关,与组织分化程度无关。
Objective：To investigate the serum squamous cell carcinoma antigen（SCCAg） in the diagnosis of cervical carcinoma,efficacy was assessed in terms of value,and its relationship with clinical stage and histological differentiation.Methods：We selected from 2011 September to 2012 March in Tianjin Central Hospital of Gynecology Obstetrics,145 patients,all suspicious cervical cancer patients,diagnosed by histopathology and divided into group CIN（55 cases） and malignant group（90 cases）.Using a chemiluminescence method for the detection of preoperative serum SCCAg concentration,combined with clinical data and histopathological diagnosis,using statistical analysis to evaluate the value of SCCAg in diagnosis of cervical cancer,and the clinical staging,histological differentiation degree of correlation,the preoperative and postoperative evaluation value of SCCAg detection in the evaluation of curative effect.Results：The serum SCCAg concentration between cervical intraepithelial neoplasia and cervical cancer having significant differences,is a good marker of squamous cell carcinoma of the cervix;after treatment,SCCAg levels decreased significantly after treatment,the difference was statistically significant（P=0.000）;according to FIGO stage,group discussion,with the progression of the disease,clinical staging of exacerbations,SCCAg higher,positive rate increased,the two have positive correlation;in suspicious cervical cancer,detection sensitivity of SCCAg is 71.1%,specificity is 72.7%,accuracy is 71.7%,and negative predictive value is 60.6%,positive predictive value is 81.0%;CIN Ⅲ positive rate was 27.3%,in stage I patients testing positive for squamous cell carcinoma of the cervix rate is 66.7%.Conclusions：Squamous cell carcinoma antigen in squamous cell carcinoma of the cervix has diagnostic value on curative effect monitoring and prognosis,also has important clinical significance in early diagnosis,but still have limitations,relation with cervical pathological types,clinical stage,and is unconcerned with tissue differentiation degree.
出处
《国际妇产科学杂志》
CAS
2013年第3期280-282,共3页
Journal of International Obstetrics and Gynecology
关键词
癌
鳞状细胞
抗原
肿瘤
宫颈肿瘤
宫颈上皮内瘤样病变
Carcinoma
squamous cell
Antigens
neoplasm
Uterine cervical neoplasms
Cervical intraepithelial neoplasia
