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普瑞巴林治疗脑卒中后中枢性疼痛的疗效观察 被引量:4

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摘要 目的:探讨普瑞巴林对脑卒中后可枢性疼痛(CPSP)的疗效。方法:70例CPSP患者随机分为普瑞巴林组和卡马西平组各35例,分别给予普瑞巴林和卡马西平治疗,4周后采用视觉模拟评分法(VAS)评价两组疗效及不良反应。结果:普瑞巴林组与卡马西平组治疗后VAS评分较治疗前均明显降低(P<0.05或0.01),且普瑞巴林组治疗后VAS评分低于卡马西平组(P<0.05),普瑞巴林组不良反应发生率低于卡马西平组(P<0.05)。结论:普瑞巴林治疗脑卒中后中枢性疼痛疗效确切,安全可靠,值得临床推广应用。
出处 《药物流行病学杂志》 CAS 2013年第6期298-299,共2页 Chinese Journal of Pharmacoepidemiology
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  • 1Nicholson BD. Evaluation and treatment of central pain syn- dromes [ J ]. Neurology, 2004,62 (5 Suppl 2) : S30-36.
  • 2Cruccu G, Anand P, Attal N, et al. EFNS guidelines on neuropathic pain assessment [ J ]. Eur J Neurol, 2004, 11 ( 3 ) : 153-62.
  • 3姚尚龙,舒化青.疼痛治疗学进展[J].临床内科杂志,2005,22(12):793-796. 被引量:16
  • 4Kumar B, Kalita J, Kumar G,et al. Central poststroke pain : a review of pathophysiology and treanrmeat [ J ]. Anesth Analg, 2009,108 (5) : 1645-1657.
  • 5Demasles S, Peyron R, Garcia Larrea L, et al. Central posrs- troke pain [J]. Rev Neurol(Paris),2008,164(10):825-831.
  • 6陈宝泉,李彩文,史艳萍,卢学磊,麻静.普瑞巴林的药理作用及临床评价[J].中国新药与临床杂志,2010,29(1):11-14. 被引量:39
  • 7Sills GJ. The michanisms of action of gabapentin and prega- balin [ J ]. Curr Opin Pharmacol,2006,6 ( 1 ) : 108-113.

二级参考文献25

  • 1BRYANS JS, WUSTROW DJ. 3-substituted GABA analogs with central nervous system activity: a review[J]. Med Res Rev,1999, 19(2):149-177.
  • 2SINGH D, KENNEDY DH. The use of gabapentin for the treatment of postherpetic neuralgia[J]. Clin Ther, 2003, 25 (3): 852-889.
  • 3PELLOCK JM. Treatment of epilepsy in the new millennium[J]. Pharmacotherapy, 2000, 20(8 Pt 2):129S-138S.
  • 4OWEN RT. Pregabalin: its efficacy, safety and tolerability profile in generalized anxiety[J]. Drugs Today (Barc), 2007, 43 (9) : 601-610.
  • 5RANDINITIS EJ, POSVAR EL, ALVEY CW, et al. Pharmacokinetics of pregabalin in subjects with various degrees of renal function[J]. J Clin Pharmacol, 2003, 43(3): 277-283.
  • 6PENOVICH PE, DICKENS DL, DOESCHER JS, et al. Pregabalin dosing and serum levels[J]. Epilepsia, 2006, 47 Suppl 4: S196.
  • 7BRODIE M J, WILSON EA, WESCHE DL, et al. Pregabalin drug interaction studies : lack of effect on the pharmacokinetics of carbamazepine, phenytoin, lamotrigine, and valproate in patients with partial epilepsy[J]. Epilepsia, 2005, 46 (9): 1407-1413.
  • 8BOCKBRADER H, MILLER R, FRAME B, et al. The concomitant use of pregabalin and oral contraceptives does not affect the efficacy of either agent[J]. Epilepsia, 2005, 46 Suppl 8: S170.
  • 9HURLEY RW, CHATTERJEA D, ROSE FENG M, et al. Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia[J]. Anesthesiology, 2002, 97 (5): 1263-1273.
  • 10HUANG CW, HUANG CC, WU SN. The opening effect of pregabalin on ATP-sensitive potassium channels in differentiated hippocampal neuron-derived H19-7 cells[J]. Epilepsia, 2006, 47 (4) : 720-726.

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