光动力疗法联合抗VEGF治疗息肉状脉络膜血管病变的临床观察被引量：3

Clinical Observation on Treatment of Polypoidal Choroidal Vascalopathy With Photodynamic Therapy Combined With Avastin

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摘要目的:观察光动力疗法(PDT)联合抗VEGF(Bevacizumab,商品名Avastin)治疗息肉状脉络膜血管病变(PCV)的治疗效果。方法:临床体征和病史结合荧光素眼底血管造影(FFA)、吲哚氰绿眼底血管造影(ICGA)及光学相干断层扫描(OCT)确诊的7例(13只眼)息肉状脉络膜血管病变患者,应用PDT联合抗VEGF药物Avastin玻璃体腔注射,每1个月～1个半月1次,连续治疗3次,随访3～24个月,随访期间复查患者最佳矫正视力,眼底病变大小与中心凹渗漏/出血吸收状态,行FFA、ICGA、OCT检查。结果:PDT联合抗VEGF治疗后1个月,患者最佳矫正视力:5只眼保持不变,3只眼提高1行,5只眼提高2行。FFA和ICGA检查显示5只眼的渗漏停止,3只眼渗漏减轻,5只眼有轻微渗漏。治疗后随诊未见其他全身及局部不良反应。结论:PDT联合抗VEGF能使PCV病灶渗漏停止或减轻,促进黄斑区出血、渗出及水肿的吸收,使患者视力稳定或改善,可作为治疗PCV的首选方法之一。

作者崔露艳马自勤惠延年

机构地区山西省晋中鹰华眼科医院

出处《山西中医学院学报》 2013年第2期62-65,共4页 Journal of Shanxi College of Traditional Chinese Medicine

关键词脉络膜病变光化学疗法维替泊芬抗VEGF药物 OCT FFA ICGA

分类号 R773.4 [医药卫生—眼科]

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