氯沙坦对室性心律失常的临床研究被引量：1

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摘要目的研究氯沙坦对室性心律失常的影响及作用。方法选择高血压合并室性心律失常的患者116例，按随机数字表法分为氯沙坦组（62例）和依那普利组（53例），两组患者年龄、性别、病程、血压、左室心肌质量指数、室性心律失常发生差异无统计学意义。入选患者给予氯沙坦（50mg，1次／d，口服）或依那普利（10mg，1次／d，口服），每周测量血压至少一次，记录血压值，疗程结束后检测患者心率、血压、描记心电图，比较两组室性心律失常的复发情况。结果依那普利治疗组患者室性心律失常减少[（3198．8±264．7）比（2035．6±207．1），t=26．42，P〈O．01]与血压下降（收缩压r=0．538，舒张压r=0．439，均P〈0．01）及左室心肌重量指数降低（r=0．567，P〈0．01）密切相关。氯沙坦治疗组患者的室性心律失常减少[（3253．7±259．9）比（654．2±195．4），t=62.94。P〈0．01）]与血压下降（收缩压r=0．098，舒张压r=0．101，均P〉0，05）及左室心肌质量指数降低（r=0．081，P〉0．05）无明显相关。结论氯沙坦与依那普利治疗后的室性心律失常发生较治疗前均明显减少，但是和依那普利相比，氯沙坦治疗有减少室性心律失常发生的趋势。

作者迟玉法赵庆

机构地区威海口腔医院内科威海卫人民医院心内科

出处《中国基层医药》 CAS 2013年第13期2036-2038,共3页 Chinese Journal of Primary Medicine and Pharmacy

关键词心律失常氯沙坦依那普利

分类号 R541.7 [医药卫生—心血管疾病]

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