摘要
目的比较氯吡格雷与丹参粉针治疗慢性脑供血不足的临床疗效,为临床治疗提供实践依据。方法选取我院2009-05—2012-12收治的120例慢性脑供血不足患者,按照随机数字表法随机分为A组与B组各60例,A组给予氯吡格雷治疗,B组给予丹参粉针剂治疗,连续治疗2周为1个疗程,比较临床疗效及血液流变学水平变化。结果治疗1个疗程后,A组总有效率91.7%,B组68.6%,A组明显高于B组,差异有统计学意义(χ2=12.063,P<0.01)。2组治疗前各项血液流变学指标比较差异无统计学意义(P>0.05),治疗后A组患者各项指标均较治疗前、B组明显改善,差异有统计学意义(P<0.05)。A组出现轻微牙龈出血3例,给予减量后消失;B组无明显不良反应发生。结论氯吡格雷治疗慢性脑供血不足效果更加理想,值得推广应用。
Objective To compare the clinical efficacy of clopidogrel and Danshen injection in treating chronic cerebral in sufficiency and provide practical basis for clinical treatment. Methods Totally 120 cases patients with chronic cerebral circula tion insufficiency in our hospital from May 2009 to December 2012 were randomly divided into A group （60 cases, clopidogrel treatment）and B group（60 cases, Danshen injection treatment）. After continuous treatment for 2 weeks, we compared the changes of the clinical curative effect and blood rheology. Results After one treatment course, the total effective rate was 91.7% （A group）or 68.6% （B group）, and the total effective rate in group A was higher than that in B group （χ^2=12. 063, P〈0.01）. The hemorheology indexes had no significant difference between two groups（P〉0.05）, and all indexes of A group after treatment had a significant improvement than these of A group before treatment and B group （P〈0.05）. Three cases in A group had some mild bleeding gums but disappeared after giving lower clopidogrel dose; patients in B group had no obvious adverse reaction. Conclusion Clopidogrel has more ideal effect to treat chronic cerebral circulation insufficiency and is worthy of popularization and application.
出处
《中国实用神经疾病杂志》
2013年第12期12-13,共2页
Chinese Journal of Practical Nervous Diseases
关键词
氯吡格雷
丹参粉针
慢性脑供血不足
Clopidogrel
Danshen injection
Chronic cerebral in sufficiency
