摘要
目的探讨三维适形放疗联合紫杉醇化疗对局部晚期非小细胞肺癌(NSCLC)的疗效及不良反应,为其临床治疗提供可参考依据。方法连续收集80例入住我院诊断为局部晚期NSCLC患者,采用随机数字法平均分为观察组、对照组,观察组患者给予三维适形放疗联合紫杉醇化疗治疗措施,对照组患者仅单独给予三维适形放疗治疗措施,观察两组患者的近期临床疗效及不良反应的发生情况。结果观察组患者总有效率62.5%明显高于对照组患者总有效率35.0%,两组间差异比较有统计学意义(P<0.05)。两组患者比较常见的不良反应有白细胞降低、血小板降低、恶性呕吐、放射性食管炎、放射性肺炎等,观察组患者上述不良反应的比例高于对照组患者,但两组间差异比较无统计学意义(P>0.05)。结论三维适形放疗联合紫杉醇化疗对局部晚期NSCLC有较好的临床疗效,可以有效抑制患者病情的发展,且不良反应发生率未有明显增加,值得临床推广应用。
Objective To observe the efficacy of three-dimensional conformal radiotherapy with concurrent chemotherapy for locally advanced Non-small cell lung cancer.Methods Continuously collected 80 cases in our hospital diagnosed with locally advanced NSCLC patients,digital method adopted randomly divided into observation group and the control group two groups,observation group patients gave three-dimensional conformal radiotherapy in combination with paclitaxel chemotherapy treatment,control group patients only gave three-dimensional conformal radiotherapy alone treatment,observed the recent clinical curative effect of two groups of patients and the occurrence of adverse reactions.Results Observation group patients were significantly higher than the control group total effectiveness 62.5% total effective rate was 35.0%,comparing difference between the two groups was statistically significant（P〈0.05）.Two groups of patients were compared with common adverse reactions were reduced white blood cells and platelets,pernicious vomiting,radioactive esophagitis,radioactive pneumonia,etc,the proportion of the observation group of patients above adverse reaction was higher than the control group of patients,but the differences between the two groups had no statistical significance（P〈0.05）.Conclusions Three dimensional conformal radiotherapy in combination with paclitaxel chemotherapy for locally advanced NSCLC has better clinical curative effect,can effectively inhibit the development of the patients,and has not significantly increased incidence of adverse reactions,worthy of clinical popularization and application.
出处
《齐齐哈尔医学院学报》
2013年第12期1722-1724,共3页
Journal of Qiqihar Medical University
关键词
三维适形放疗
紫杉醇
非小细胞肺癌
疗效
Three dimensional conformal radiotherapy
Paclitaxel
Non-small cell lung cancer
Curative effect
