摘要
目的探讨自拟方剂联合放化疗治疗老年食管癌的临床疗效。方法将甘肃省武威市人民医院2008年2月～2011年2月收治的120例老年食管癌患者分为对照组与观察组,对照组60例采用三维适形放射治疗联合顺铂同步化疗,观察组60例在对照组的基础上联合自拟方剂治疗。比较两组的临床疗效、近期生存质量、副作用以及疾病进展时间(TTP)、中位生存期(MST)等。结果对照组总有效(CR+PR)率为31.7%(19/60),明显低于观察组[58.3%(35/60)],差异有高度统计学意义(P<0.01);对照组患者治疗后生存质量得分为(102±7)分,观察组为(131±8)分,差异有高度统计学意义(P<0.01),但两组副作用比较差异无统计学意义(P>0.05);观察组TTP与MST均比对照组早,两组TTP比较差异有统计学意义(P<0.05)。结论自拟方剂联合放化疗治疗老年食管癌,其临床效果尤佳,患者短期生存质量有所提高,值得在临床上加以推广并应用。
Objective To study the curative effect of self-made prescription combined with chemoradiotherapy for elderly esophageal cancer. Methods 120 cases of elderly patients with esophageal cancer admitted to Wuwei People＇s Hospital of Gansu Province from February 2008 to February 2011 were divided into control group and observation group. 60 cases of control group were taken three-dimensional conformal radiotherapy in combination with Cisplatin synchronous chemotherapy; 60 cases of observation group were taken the self-made prescription on basis of control group. The clinical curative effect, the recent survival quality, adverse reactions and time to progression （TTp）, median survival time （MST） of the two groups were compared. Results The total effective rate （CR＋PR） of control group was 31.7% （19/60）, significantly lower than the observation group [58.3% （35/60）], the difference was statistically significant （P 〈 0.01）; after treatment, survival quality score of control group was （102＋7） points, which of observation group was （131＋8） points, the difference was statistically significant （P 〈 0.01）, but the difference of adverse reactions between the two groups was not significant （P 〉 0.05）; TTP and MST of observation group were earlier than the control group, TTP of the two groups had a statistically significant difference （P 〈 0.05）. Conclusion Self-made prescription combined with chemoradiotherapy for elderly esophageal cancer has a good clinical effect, the short-term survival quality of patients are improved, which should be popularized in clinical application.
出处
《中国医药导报》
CAS
2013年第19期112-114,共3页
China Medical Herald
基金
甘肃省武威市卫生局重点支持项目(编号WW2009A028)
关键词
自拟方剂
放化疗
老年食管癌
Self-made prescription
Chemoradiotherapy
Elderly esophageal cancer
