摘要
目的探讨精神心理因素与反流性食管炎(reflux esophagitis,RE)的关系及抗抑郁治疗的效果。方法对186例RE患者行汉密顿焦虑量表(HAMA)及汉密顿抑郁量表(HAMD)评分,观察常规治疗对HAMA、HAMD的评分影响。142例经常规治疗症状未见改善者,随机分为常规组和综合组,综合组在常规治疗基础上联合疏肝健脾汤用药,观察其治疗后两组患者HAMA、HAMD评分及临床症状积分变化。结果 RE患者焦虑、抑郁症发生率高于普通人群;常规治疗后HAMA、HAMD评分有所下降;而综合组联合治疗后,其HAMA、HAMD评分显著下降(P值分别为0.028与0.009)。结论 RE与精神心理因素有关,抗抑郁治疗能提高反流性食管炎治疗的临床疗效。
Objectives To explore the relationship and effect of antidepressant treatment between psy-chiatric and psychological factors and reflux esophagitis（RE）. Methods 186 patients with RE were evaluated with Hamilton＇s anxiety scale（HAMA） and Hamilton＇s depression seale（HAMD）. After treatment of proton pump inhibitor （PPI）, the score were observed patients who were abnormal in HAMA and HAMD. The other 142 patients were di vided randomly into a conventional group and a integrated group： The conventional group treated with PPI,the integrated group treated with Paroxetine and PPI. Then the changes of the HAMA, HAMD and clinical score were ob served. Results The rate of RE with anxiety and depression was higher than the healthy population. The HAMA and HAMD score were lower post-treatment with PPI. In the integrated group,the HAMA and HAMD were de creased （P=0. 028, P=0. 009）. Conclusions RE is related to psychiatric and psychological factors. Antidepressant treatment may contribute to the imDrovement of curative effects.
出处
《中国社会医学杂志》
2013年第3期196-197,共2页
Chinese Journal of Social Medicine
基金
湖北省卫生厅立项项目(ZX6C-38)
2012武汉市市级人才工程人选科研择优资助项目
关键词
反流性食管炎
精神心理因素
治疗
Reflux esophagitis
Psychiatric and psychological factors
Treatment
