摘要
研究辐射交联制备聚乙烯醇/聚丙烯酸钠/丙烯酰胺(PVA/PAAS/AM)聚合物水凝胶伤口敷料的方法、影响因素和性能,旨在提高水凝胶敷料对伤口渗出液的吸液能力。采用正交试验设计法,将PVA,PAAS和AM制成混合液,经高温溶解为均一溶液,经电子束辐照合成膜状水凝胶。对水凝胶膜进行了红外光谱、溶胀度、抗张强度等理化性能测试。结果显示,以水凝胶敷料吸液性能作为判定标准,PAAS、PVA和AM最佳配比为26:2:9,其生理盐水溶胀度高达(4582.5±316.3)%。该系列水凝胶膜三蒸水溶胀度最高为(46850.8±4256.7)%,抗张强度可高达(2.677±0.752)Mpa。结果提示,采用三元辐射聚合法制备出一种新型的PVA/PAAS/AM水凝胶敷料,在离子型溶液中吸液性能明显优于国内外水凝胶敷料,为进一步临床应用奠定了基础。
In this paper, the preparation influencing factors of PVA-PAAS-AM hydrogel wound dressings were investigated under electron accelerator irradiation. Physical and chemical properties were tested at the same time. This approach was designed to improve hydrogel wound dressings pipette ability in the body exudates environment. Poly acrylate sodium （PAAS） and polyvinyl alcohol （PVA） and AM （Aerylamide） were selected for this study by an orthogonal experimental design method, dissolved into a homogeneous aqueous solution at high temperature, and the new polymer hydrogel was synthesized by the electron accelerator radiation. Performance testing of the infrared spectra, the swelling degree and the tensile strength of hydrogel membrane were carried out. If we considered the hy- drogel dressing by liquid absorbing capacity as criteria, the best ratio of PAAS, PVA and AM was 26： 2： 9, the degree of swelling in saline was （4,582.5±316.3）%. The triple-distilled water swelling degree in the series of the hydrogel membrane was up to （46850.8 ± 4256.7）%, the tensile strength was up to （2.677 ±0.752） MPa. A salt tolerant hydro- gel dressing was prepared by using a terpolymer. The capacity of the new type of PVA/PAAS/AM hydrogel dressing was superior to current products and this work laid a foundation for further clinical applications.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
2013年第3期44-50,共7页
Journal of Radiation Research and Radiation Processing
基金
国家自然科学基金(81072236)
国防基础科研资助(A3820060138)
江苏高校优势学科建设工程项目资助
关键词
水凝胶敷料
辐射
耐盐性
聚乙烯醇
聚丙烯酸钠
丙烯酰胺
Hydrogel wound dressings, Radiation, Salt tolerance, Poly vinyl alcohol, Poly acrylate sodium, Acrylamide
