摘要
雷公藤甲素为雷公藤的主要活性成分之一,也是雷公藤片、雷公藤多苷片等制剂的主要有效成分。它具有抗炎、抗肿瘤、免疫调节等药理作用,是热点研究的天然活性化合物。但是,雷公藤甲素的副作用在很大程度上影响了其在临床上的应用,其中对生殖系统的毒性及抗生育作用尤为明显,特别是对雄性生殖系统的影响。综述了雷公藤甲素对男性睾丸、附睾和精子等,以及对女性生殖系统的损害及作用机制,并建议系统开展配伍减毒增效的研究,实现对配伍雷公藤甲素安全窗口的拓宽优化,为安全有效地应用于临床提供有力依据。
Triptolide is one of the main active constituents in Tripterygium wilfordii. It is the main effective component of T. wilfordii preparations. Triptolide has the anti-inflammatory, antitumor, and immunomodulatory effects, which is a natural active drug attracting research focus. However, to a large extent, the side effects of triptolide limitted the clinical applications. The toxicities on the reproductive system and the antifertility effect are particularly obvious, especially the male reproductive system. In this paper, the information was collected and analyzed to summarize the damage mechanisms of triptolide on male testes, epididymis, sperm, and female reproductive system as well. Besides, the further studies should be carried out on the detoxification and enhancement action, so as to broaden and optimize the security window of triptolide, and to provide a powerful basis for its safety and effect on the clinical application.
出处
《药物评价研究》
CAS
2013年第3期224-227,共4页
Drug Evaluation Research
基金
福建省自然科学基金项目(2013J01367)
福建省科技重大专项(2009YZ0001-1-3)
福建省省属公益类科研院所基本科研专项(2011R1034-3)
福建省卫生厅青年科研基金项目(2012-1-14)
关键词
雷公藤
雷公藤甲素
生殖
毒性
Tripterygium wilfordii Hook. f.
triptolide
reproduction
toxicity
