摘要
红景天苷及其苷元酪醇是存在于红景天属、越桔属、杜鹃花属、女贞属等植物中的天然抗氧化剂,通过提高细胞的抗氧化能力,清除活性氧,调控炎性细胞因子表达和抑制炎症介质合成,从而产生抗炎作用和防止癌变的发生。红景天苷能上调几种细胞周期蛋白依赖激酶抑制因子表达,减少细胞周期蛋白依赖激酶Cdc2和细胞周期蛋白B1表达,使癌细胞周期滞留在G2期,抑制癌细胞生长。红景天苷对非特异性免疫、体液免疫和细胞免疫均有提高作用,也能对抗免疫抑制剂对骨髓造血功能的抑制。女贞子中的红景天苷和酪醇含量亦很高,因此应加强来源植物女贞子的化学、药理和药效研究。
Salidroside and its aglycone tyrosol are natural anti-oxidants from the plants of Ligustrum Linn., Rhododendron L., Vaccinium L., Rhodiola L., and so on. Salidroside could both produce anti-inflammation and prevent carcinogenesis through increasing the anti-oxidative potency of cells, scavenging the reactive oxygen species, modulating the expression of inflammatory cytokine, inhibiting the inflammatory mediators synthesis, and preventing the canceration. Salidroside up-regulates the expression of various cyclin-dependent kinase inhibitors, down-regulates the expression of cycin-dependent kinase Cdc-2 and cyclin B1 for the cell cycle G2-phase retention, and results in the inhibition on the growth of cancer cells. Salidroside promotes nonspecific, humoral, and cellular immunocompetence, and antagonizes to the immunosuppressants in depressing the hematopoietic function of the bone marrow. The contents of salidroside and tyrosol are considerably high in Ligustri Lucidi Fructus, and so it is significant to strengthen the studies of Ligustri Lucidi Fructus in chemistry, pharmacology, and pharmacodynamics.
出处
《药物评价研究》
CAS
2013年第3期228-234,共7页
Drug Evaluation Research
关键词
红景天苷
酪醇
抗炎
抗肿瘤
免疫调节
女贞子
salidroside
tyrosol
anti-inflammation
anti-tumor
immunoregulation
Ligustri Lucidi Fructus
