摘要
目的:研究新型毒品(K粉、摇头丸、麻古)长期使用对机体免疫功能的影响。方法:收集50例新型毒品滥用者的住院资料和50例性别、年龄相匹配正常人作为对照组,测定免疫功能、自身抗体及补体,根据结果进行独立样本t检验统计分析。结果:新型毒品滥用者免疫指标较对照降低,CD4/CD8(P<0.05)具有统计学意义,试验组与对照组比较,IgG、IgM、C3、C4的变化均有统计学意义,自身抗体均为阴性,无统计学意义;结论:试验组与对照组相比免疫功能有不同程度的损害,新型毒品对免疫功能的影响除了与中枢神经系统的阿片受体、μ受体等有关,还涉及许多的未知的信号途径,这对以后的研究都有重要意义。
Objective：To investigate the influence of synthetic drugs（katemine,ecstasy,Magu） on immunologic function in abusers.Methods：The hospitalization data of 50 cases of synthetic drug-abusers and 50 controls were collected,genders and ages were matched in these two groups.The immunologic function,autoantibody and addiment were detected based on the results of the independent sample t-test statistical analysis.Results：There were statistically significant differences in immune indicators CD4/CD8（P0.05）,IgG,IgM,C3 and C4 compared with the control group,but the autoantibodies between two groups were not statistically significant.Conclusion：There are significant differences of impaired immunologic function in drug abused group compared with the control group.The effect of synthetic drugs on immunologic function is related to the impact on the opioid receptors and μ receptor in the central nervous system,and many unknown signaling pathways.
出处
《中国药物依赖性杂志》
CAS
CSCD
2013年第3期227-230,共4页
Chinese Journal of Drug Dependence
关键词
新型毒品
免疫功能
自身抗体
T细胞
synthetic drugs
immunologic function
autoantibody
T cell
