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硅噻菌胺合成新工艺 被引量：5

A New Process for Synthesis of Silthiopham
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摘要 [目的]硅噻菌胺是小麦全蚀病选择性防治药剂,然而该药剂的规模合成存在着很大挑战,为此,研究开发了硅噻菌胺的新合成工艺。[方法]该工艺以3-氯-2-丁酮、丙炔酸甲酯为起始原料,通过取代、环合、硅烷化和酰胺化等4步反应,方便地得到目的产物。[结果]该工艺具有原料易得、反应易控、反应媒介易于回收使用、单步收率高等特点。[结论]具有工业应用前景。 [Aims] Silthiopham was a selective fungicide for the control of take-all disease.However,its scale preparation faced big challenges.So,a new process was explored.[Methods] Silthiopham was afforded conveniently by using 3-chlorobutan-2-one and methyl propiolate as starting materials in four steps via substitution,cyclization,silylanization and amidation.[Results] The procedure showed several advantages such as easily available raw materials,mild reaction conditions,easily recycled reaction medium and high single-step yields.[Conclusions] It could be applied to industrial production.
作者 靳文波 谢桂英 孙淑君 游秀峰 李洪连 程绎南
机构地区 河南农业大学植保学院 河南农业大学新型农药创制与应用河南省重点实验室
出处 《农药》 CAS CSCD 北大核心 2013年第7期484-486,共3页 Agrochemicals
关键词 硅噻菌胺 小麦全蚀病 成环反应 硅烷化 合成 silthiopham take-all disease cyclization reaction silylanization synthesis
分类号 TQ455.4 [化学工程—农药化工]
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参考文献8

  • 1COOK R J. Take-all of Wheat[J]. Physiological and Molecular Plant Pathology, 2003, 62: 73-86.
  • 2PHILLION D, WONG S C, SHORTT B. Fungicides for the Control of Take-all Disease of Plants: US, 5486621 [P]. 1996-01-23.
  • 3JOSEPH-HORNE T, HEPPNER C, HEADRICK J, et al. Identification and Characterization of the Mode of Action of MON 65500: A Novel Inhibitor of ATP Export from Mitochondria of the Wheat"Take-All" Fungus, Gaeumannomyces graminis var. tritici[J]. Pesticide Biochemistry and Physiology, 2000, 67: 168- 186.
  • 4李莉,顾峰雷,诸坤,邱化玉.有机铵盐促进Gewald反应合成多取代2-氨基噻吩类化合物的研究[J].杭州师范大学学报（自然科学版）,2011,10(1):52-55. 被引量：7
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二级参考文献14

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共引文献6

同被引文献38

引证文献5

二级引证文献8

农药
2013年 第7期

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