摘要
目的:研究活骨丹胶囊对实验大鼠激素性股骨头坏死模型的血液流变学、血脂、血钙、骨代谢等指标的影响。方法:取清洁级健康SD大鼠60只,雌雄各30只,按体重随机分成空白组,模型组,阳性对照药仙灵骨葆胶囊组(0.28 g.kg-1),活骨丹胶囊高、中、低剂量组(1.80,0.90,0.45 g.kg-1)。除空白组外,各组每周1次大腿内侧im醋酸泼尼松龙(24.5 mg.kg-1),连续8周造模,在造模的同时,各给药组均灌胃给药,模型组和空白组给予等量蒸馏水,预防性灌胃给药8周后取血测定大鼠全血黏度,血浆黏度,血沉K值,血清总胆固醇(CHO),甘油三酯(TG)的含量,血清碱性磷酸酶(ALP),酸性磷酸酶(ACP),血钙(Ca),血磷(P)的含量。结果:与空白组比较,模型组中高、中、低各组切变率下的全血黏度均显著升高(P<0.01),血沉K值及血浆黏度均显著升高(P<0.01),血清中CHO,TG,ALP的含量均显著升高(P<0.01),血清Ca含量升高(P<0.05)。与模型组比较,活骨丹胶囊各剂量组可明显增加血清中的Ca,P含量,同时降低ALP和ACP的活性,降低全血黏度,血浆黏度及血脂,差异有显著性意义(P<0.05,P<0.01)。结论:活骨丹对于骨质破坏所引起的ALP,ACP升高有一定的拮抗作用,同时能降低血脂,调节血清中的Ca,P沉积,增加骨密度。
Objective： To study the effect of Huogu Dan capsule on hemorheology,blood lipids,blood calcium and bone metabolism indicators of avascular necrosis of femoral head by hormone in rats.Method： Sixty SD rats were divided into 6 groups,the control group,the model group,the high,medium,low-dose group（1.80,0.90,0.45 g.kg-1）,the positive drug group（0.28 g.kg-1）.Except the normal group,each group was im given once a week prednisolone（24.5 mg.kg-1）.Meanwhile each dose group was ig Huogu dan capsule.After 8 weeks rats were sacrificed to collect blood from carotid artery for determination of the whole blood viscosity,plasma viscosity,ESR,the serum total cholesterol（CHO）,triglycende（TG）,alkaline phosphatase（ALP）,acid phosphatase（ACP）,serum calcium（Ca） and phosphorus（P）.Result： Compared with the control group,the whole blood viscosity in the model group was significantly increased（P〈0.01）.ESR values and plasma viscosity were significantly increased（P〈0.01）.CHO,TG and ALP levels were significantly increased（P〈0.01）.Ca level was increased（P〈0.05）.Compared with model group,Ca and P levels were significantly increased in the Huogu dan group,ALP and ACP were reduced,whole blood viscosity,plasma viscosity and blood lipids were reduced,statistical significance is different（P〈0.05,P〈0.01）.Conclusion： The Huogu Dan capsule can be significantly increased Ca and P levels,and reduce ALP,ACP levels,whole blood viscosity,plasma viscosity and blood lipids.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第13期250-253,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
激素性股骨头坏死
活骨丹胶囊
血液流变学
glucocorticoid-induced avascular necrosis of femoral head
Huogu Dan capsule
hemorheology
