摘要
OBJECTIVE： Appropriate dose guarantees Chinese herb＇s safety and effectiveness. There are adult dose criteria for Chinese herbs in decoction in the Pharmacopoeia of the People＇s Republic of China （2010 Edition） at present. But Chinese herbs have been frequently used in much higher doses than the dose criteria. This study has been conducted to test the dependability of the dose criteria. METHODS： Twenty Chinese herbs were selected as representatives and their adult doses in decoction in Bei Ji Qian .lin Yao Fang, a famous ancient litera- ture, have been reviewed and compared with those in the Pharmacopoeia of the People＇s Republic of China （2010 Edition）. RESULTS： The adult dose criteria for all these 20 Chinese herbs in the Pharmacopoeia of the People＇s Republic of China （2010 Edition） haven＇t covered those in Bei Ji Qian .fin Yao Fang. Furthermore, maxi- mal adult doses in the dose criteria are much lower than those in Bei Ji Qian Jin Yao Fang. CONCLUSION： The dose criteria in the Pharmaco- poeia of the People＇s Republic of China （2010 Edition） are not comprehensive enough. Studying ancient literatures is an effective method to gain preciousChinese herbs＇ dose data and helps for new dose criteria＇s establishment in the future.
OBJECTIVE:Appropriate dose guarantees Chinese herb's safety and effectiveness.There are adult dose criteria for Chinese herbs in decoction in the Pharmacopoeia of the People's Republic of China(2010 Edition) at present.But Chinese herbs have been frequently used in much higher doses than the dose criteria.This study has been conducted to test the dependability of the dose criteria.METHODS:Twenty Chinese herbs were selected as representatives and their adult doses in decoction in Bei Ji Qian Jin Yao Fang,a famous ancient literature,have been reviewed and compared with those in the Pharmacopoeia of the People's Republic ofChina(2010 Edition).RESULTS:The adult dose criteria for all these 20 Chinese herbs in the Pharmacopoeia of the People's Republic of China(2010 Edition) haven't covered those in Bei Ji Qian Jin Yao Fang.Furthermore,maximal adult doses in the dose criteria are much lower than those in BeiJiQianJinYaoFang.CONCLUSION:The dose criteria in the Pharmacopoeia of the People's Republic of China(2010 Edition) are not comprehensive enough.Studying ancient literatures is an effective method to gain precious Chinese herbs' dose data and helps for new dose criteria's establishment in the future.
基金
Supported by Shanghai Municipal Education Commission Budget for Research Projects (No. 2011JW68)
