摘要
OBJECTIVE: To investigate the therapeutic effect of the herbal medication Xiao Pi-II on the symptoms and gastric motility of patients with functional dysepsia (FD). METHODS: A total of 180 FD patients were divided randomly and equally into Xiao Pi-II and mosapride groups. The two groups were treated with Xiao Pi-II (100 mL, t.d.s., ante cibum) and mosapride (5 mg, t. d.s., ante cibum) for 2 weeks. Before treatment and 3 days after all medication was stopped, patients responded to a questionnaire evaluating gastrointestinal symptoms and were assessed with abdominal three dimensional ultrasonography (3D-US) for gastric motility. RESULTS: Gastrointestinal symptoms (especially bloating, post-prandial fullness and eructation) were improved significantly in FD patients treated with Xiao Pi-II (P<0.05, P<0.05, and P<0.05), but no significant difference was found in the mosapride group (P>0.05). The effective rates in the Xiao Pi-II and mosapride group were 86.7% and 60.0%, respectively (P<0.05). The gastric liquid emptyingrate (GLER) in the Xiao Pi-II group showed a significant increase (P<0.01) after 2 weeks of treatment but there was no significant change (P>0.05) of GLER in the mosapride group. CONCLUSION: Compared with mosapride, Xiao Pi-II improved symptoms and GLER significantly in FD patients with delayed gastric emptying.
OBJECTIVE： To investigate the therapeutic effect of the herbal medication Xiao Pi-II on the symptoms and gastric motility of patients with functional dys- epsia （FD）. METHODS： A total of 180 FD patients were divided randomly and equally into Xiao Pi-II and mosapride groups. The two groups were treated with Xiao Pi-II （100 mL, t.d.s., ante cibum） and mosapride （5 mg, t. d.s., ante cibum） for 2 weeks. Before treatment and 3 days after all medication was stopped, patients re- sponded to a questionnaire evaluating gastrointes- tinal symptoms and were assessed with abdominal three dimensional ultrasonography （3D-US） for gas- tric motility. RESULTS： Gastrointestinal symptoms （especially bloating, post-prandial fullness and eructation） were improved significantly in FD patients treated with Xiao Pi-II （P〈0.05, P〈0.05, and P〈0.05）, but no significant difference was found in the mosapride group （P〉0.05）. The effective rates in the Xiao Pi-II and mosapride group were 86.7% and 60.0%, re- spectively （P〈0.05）. The gastric liquid emptyingrate （GLER） in the Xiao Pi-II group showed a signifi- cant increase （P〈0.01） after 2 weeks of treatment but there was no significant change （P〉0.05） of GLER in the mosapride group. CONCLUSION： Compared with mosapride, Xiao Pi-II improved symptoms and GLER significantly in FD patients with delayed gastric emptying.
