期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

先天性胫骨假关节的病因学研究进展 被引量：8

下载PDF
导出
摘要 先天性胫骨假关节（congenital pseudarthrosis of the tibia，CPT）是由于发育异常导致的胫骨畸形，表现为胫骨成角畸形、髓腔狭窄或囊肿等，最终形成不愈合的假关节。其发生率占新生儿的1／140000～1／250000。先天性胫骨假关节是骨科领域了解较少、治疗极其困难的疾病。从1709年Hatzoecher首先报告本病以来，已有300余年历史，病因至今不完全清楚。曾有多种学说，如宫内压迫、产伤、血运障碍、全身代谢性疾病等，但都缺乏充足的证据。该病与1型神经纤维瘤病（NF1）存在复杂关系。本文从该病的病理学特点、骨发育相关细胞因子的表达、遗传学与基因学研究、及与1型神经纤维瘤病的关系等方面综述其病因学研究进展。
作者 汤用波(综述) 梅海波(审校)
机构地区 南华大学儿科学院 湖南省儿童医院
出处 《临床小儿外科杂志》 CAS 2013年第3期234-236,254,共4页 Journal of Clinical Pediatric Surgery
关键词 先天性胫骨假关节 病因学 1型神经纤维瘤病 全身代谢性疾病 相关细胞因子 病理学特点 胫骨畸形 发育异常
分类号 R681.8 [医药卫生—骨科学]
  • 相关文献

参考文献29

  • 1Pannier S. Congenital pseudarthrosis of the tibia[ J] . OrthopTraumatol Surg Res,2011 ;97(7) :750-61.
  • 2Ippolito E,Corsi A,Grill F, et al. Pathology of bone lesionsassociated with congenital pseudarthrosis of the leg[ J]. Ped-iatr Orthop B,2000;9( 1) :3-10.
  • 3Hannu-Ville Leslcela, Tommi kuorilehto, Juha Risteli. Con-genital pseudarthrosis of neurofibromatosis typel : Impairedexpression osteoblast differentiation and function and alteredNF1 gene[J]. Bone ,2009,44:243 -250.
  • 4Akio Sakamoto, Tatsuya Yoshida, Hidetaka Yamamotoz, etal. Congenital pseudarthrosis of the tibia analysis of the his-tology and the NF1 gene [ J ]. Orthop Sci,2007,12 : 361 -365.
  • 5RocioP Mariaud-Schmidt, Sergio Rosales-Quitana, et al.Hamartoma Involving the Pseudarthrosis Site in Patients WithNeurofibromatosis Type 1 [ J ]. Pediatric and DevelopmentalPathology,2005,8:190-196.
  • 6Al-Hadidy A, Haroun A, Al-Ryalat N,et al. Congenitalpseudoarthrosis associated with venous malformation [ J ].Skeletal Radiol,2007,36: 15-18.
  • 7Tommi Kuorilehto, Pentti Kinnunen, Marja Nissinen, et al.Vasculopathy in two cases of NF1 - related congenitalpseudarthrosis [ J ]. Pathology-Research and Practice, 2006,202:687-690.
  • 8Benita Hermanns - Sachweh, Jan Senderek, Joachim Alfer,et al. Vascular changes in the periosteum of congenitalpseudarthrosis of the tibia [ J ]. Pathology-Research andPractice,2005 ,201 ;305-312.
  • 9Granchi D, Devescovi V,Baglo SR. Biological basis for theuse of autologous bone marrow stromal cells in the treatmentof congenital pseudarthrosis of the tibia[ J]. Bone,2010,46(3) :780-788.
  • 10Cho TJ,Seo JB,Lee HR,et al. Biologic characteristics offibrous hamartoma from congenital pseudarthrosis of the tib-ia associated with neurofibromatosis type 1 [ J ]. Bone JoihtSurg Am,2008,90( 12) :2735-2744.

二级参考文献7

  • 1Emi D, De Kerviler S, Hertel R, et al. Vascularised fibula grafts for early tibia reconstruction in infants with congenital pseudarthrosis [ J ]. J Plast Reconstr Aesthet Surg, 2010,6~3 (10) :1699-704.
  • 2Johnston CE. Congenital pseudarthrosis of the tibia: results of technical variations in the Charnley - Williams procedure [ J ]. J Bone Joint Surg Am, 2002,84 : 1799-1810.
  • 3Ohnishi I, Sato W, Matsuyama J. Treatment of congenital pseudarthrosis of the tibia: a multicenter study in Japan [ J ]. J Pediatr Orthop,2005 ,25 :219-224.
  • 4Brinker MR. Nonunions: evaluation and treatment. In: Brow- ner BD, Jupiter JB, Levine AM, et al, editors. 3rd edition [ M ]. Skeletal Trauma Basic science management and recon- struction ,vol. 1. Philadelphia : Saunders ,2003,507 -604.
  • 5Giannoudis PV, Dinopoulos HT. Autologous Bone Gr.aft: When Shall We Add Growth Factors [ J ]. Orthop Clin N Am, 2010,41:85-94.
  • 6Vitale MG, Roye JR D P, Choi IH. Treatment of Congenital Pseudarthrosis of the Tibia with Recombinant Human Bone Morphogenetic Protein - 7 ( rhBMP - 7 ) [ J ]. J Bone Joint Surg Am ,2006,88:627-633.
  • 7Kim HW, Weinstein SL. Intramedullary fixation and bone grafting for congenital pseudarthrosis of the tibia [ J ]. Clin Orthop Relat Res,2002 ,405 :250-257.

共引文献15

同被引文献49

引证文献8

二级引证文献7

临床小儿外科杂志
2013年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部