摘要
目的:评价龙胆泻肝汤治疗胆腑郁热型慢性鼻-鼻窦炎的临床疗效。方法:选取患者30人予以龙胆泻肝汤水煎剂口服,治疗前后分别评价患者主观指标(SF-36、VAS及SNOT-20量表)和客观指标(鼻腔分泌物IL-8水平)变化情况。结果:1.中医证候积分变化:治疗后证候积分改善明显,统计学处理有显著性差异。2.鼻腔分泌物IL-8水平变化:治疗前后IL-8水平差异明显。3.患者生存质量变化:除SF-36外,VAS量表与SNOT-20量表评分治疗前后比较有统计学差异。结论:龙胆泻肝汤能有效改善患者流脓涕、头痛等症状,并降低鼻腔IL-8水平,为延缓慢性鼻-鼻窦炎的发展起到了一定的治疗作用。
Objective： The clinical study is conducted to observe the the clinical curative effect of longdan xiegan decoction in the treatment of chronic rhinosinusitis in patients with depressed gall-bladder with phlegm-heat through Quality of Life Scale.Methods： 30 patients of chronic rhinosinusitis with depressed gall-bladder with phlegm-heat were observed.Subjects received longdan xiegan decoction daily for 2 weeks.Outcome measures included the Sinonasal Outcome Test-20（SNOT-20）,VAS scale,SF-36 scale,measurements of nasal lavage assays for interleukin-8.Results： There were statistically significant improvements in SNOT-20 score and VAS scale as well as IL-8 levels in lavage fluid（P 0.05） after the treatment.No significant improvements were noted for SF-36 scale.Conclusion： Through the preliminary clinical study,longdan xiegan decoction plays a significant role in the improvement of clinical symptoms to reduce the pain index,lower inflammatory activity,enhance the quality of life.
出处
《成都中医药大学学报》
2013年第2期39-41,共3页
Journal of Chengdu University of Traditional Chinese Medicine
基金
四川省教育厅基金项目(编号:11ZB183)
关键词
慢性鼻-鼻窦炎
胆腑郁热证
Long-dan-xie-gan decoction
chronic rhinosinusitis
depressed gall-bladder with phlegm-heat
