摘要
目的观察左卡尼汀治疗扩张型心肌病的临床疗效。方法选择扩张型心肌病的患者58例,随机分为左卡尼汀组(治疗组)和对照组,每组各29例。对照组口服ACE-I和β受体阻滞剂,治疗组在对照组基础上加用静脉滴注左卡尼汀2 g/d,连续14 d,治疗14 d后,比较2组患者治疗前后及组内LVEF、6 min步行实验及NVHY心功能分级改善情况。结果 2组治疗前后及2组比较,LVEF差异有统计学意义(P<0.05);6 min步行实验各组治疗前后及2组比较,差异有统计学意义(P<0.05);LVEDd各组治疗前后差异统计学意义(P<0.05),2组比较差异无统计学意义(P>0.05),治疗组NYHA分级总有效率显著高于对照组(P<0.05)。结论左卡尼汀能有效改善扩张性心肌病患者的血流动力学状态及心功能,值得临床推广。
Objective To evaluate the clinical efficacy of levocarnitine in the treatment of dilated cardiomyopathy （DCM）. Methods A total of 58 patients with DCM were randomly divided into a treatment group and a control group. The patients in the control group were treated with ACE-I and β-blocker and the patients in the treatment group were additionally added the intravenous infusion of levocamitine 2g/d, for 14 days. Fourteen days after the treatment, the LVEDd, LVEF, results of 6-minute walk tests and NVHY cardiac function improvements were analyzed and compared. Results Before and after the treatment, the LVEF（s） between the two groups were significantly different （P 〈 0.05）. Before and after treatment and between the two groups, the results of the 6 minute walk tests were significantly different （P〈 0.05）. Before and after the treatment, the LVEDd（s） were significantly different, but there was no significant difference between the two groups （P 〉 0.05）. The total efficiency in the NYH class of the treatment group was significantly higher than that of the control group （ P 〈 0.05 ）. Conclusions The levocamitine can improve the hemodynamic status and cardiac function of patients with DCM.
出处
《中国校医》
2013年第6期463-464,共2页
Chinese Journal of School Doctor
关键词
心肌病
扩张型
药物疗法
肉碱
Cardiomyopathy, Dilated/drug therapy
Camitine
