摘要
目的探讨青蒿琥酯(Artesunate,Art)对小鼠脾淋巴细胞增殖的影响。方法采用四甲基偶氮唑蓝法分别检测Art对正常和刀豆蛋白A诱导的小鼠脾细胞增殖的影响。结果 Art对正常增殖的淋巴细胞活性无明显影响;剂量≥12.5μg/mL时,对刀豆蛋白A诱导的淋巴细胞增殖表现出较强的抑制活性(P<0.01),且抑制作用随药物浓度的增加而提高。结论 Art具有较强的抑制淋巴细胞增殖活性。
Objective To investigate the effect of artesunate（Art） on spleen lymphocyte proliferation in vitro.Methods Art on the mouse spleen lymphocyte proliferation with or without ConA in vitro were determined by a MTT assay.Results Art（≥12.5 μmol/L） significantly inhibited the proliferation of lymphocytes induced by ConA（P 0.01） while no obvious influences on lymphocyte proliferation were observed in groups without ConA.Conclusion Art showed a good immunoactivity.
出处
《基层医学论坛》
2013年第19期2477-2479,共3页
The Medical Forum
