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甘露糖结合凝集素在先天性免疫中的作用 被引量：2

Roles of Mannose-Binding Lectin in Innate Immunity
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摘要 本文主要从模式识别、激活补体系统、调理吞噬、参与炎症反应几个方面介绍甘露糖结合凝集素在先天性免疫中的作用. Mannose-binding lectin （MBL） is an important involved in pattern recognition, activation of complement reviewed. component of complement system. The roles of MBL system, opsonization, and inflammatory response were
作者 卜令真 张士璀
机构地区 中国海洋大学海洋生命学院
出处 《鲁东大学学报（自然科学版）》 2013年第3期229-233,共5页 Journal of Ludong University:Natural Science Edition
基金 国家自然科学基金(30972274)
关键词 甘露糖结合凝集素 模式识别 调理作用 补体系统 炎症反应 mannose-binding lectin pattern recognition complement activation opsonization inflammatory re- sponse
分类号 R392.11 [医药卫生—免疫学]
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参考文献38

  • 1Takahashi K. Mannose-binding lectin and the balance between immune prorection and complication[J] .Ex?pert Rev Anti Infect Ther ,2011 ,9( 12) : 1179-1190.
  • 2Takahashi K, Ezekowitz R A. The role of the mannose- binding lectin in innate immunity[J] . Clin Infect Dis, 2005,41 (S7) :S440-S444.
  • 3Degn S E,JenseniusJ C, Thiel S. Disease-causing mu?tations in genes of the complement system[J]. AmJ Hum Genet,2011 ,88(6) :689-705.
  • 4Janeway C A. Approaching the asymptote? Evolution and revolution in immunology[J]. Cold Spring Harb Symp Quant Biol , 1989 ,54 : 1 - 13.
  • 5Gadjeva M, Takahashi K, Thiel S. Mannan-binding lectin-a soluble pattern recognition molecule[J] . Mol Immunol,2004,41 (2/3) :113-121.
  • 6Jack D L, Dodds A W, Anwar N, et al. . Activation of complement by mannose-binding lectin on isogenic mutants of Neisseria meningitidis serogroup B[J].J Immunol, 1998,160(3) : 1346-1353.
  • 7Jack D L, Klein NJ, Turner M W. Mannose-binding lectin: targeting the microbial world for complement attack and opsonophagocytosis[J]. Immunol Rev, 2001,180:86-99.
  • 8Jack D L, Read R C , Tenner AJ , et al. Mannose-bind?ing lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B[J] .J Infect Dis, 200 1 , 184 (9) :1152-1162.
  • 9Gulati S,Sastry K,JenseniusJ C,et al. Regulation of the mannan-binding lectin pathway of complement on Neisseria gonorrhoeae by Cl-inhibitor and alpha 2- macroglobulin] J].J Immunol, 2002, 168 ( 8 ) : 4078 -4086.
  • 10Hart M L,Saifuddin M,Spear G T. Glycosylation inhibitors and neuraminidase enhance human immuno-deficiency virus type 1 binding and neutralization by mannose?binding lectin[J].J Gen Virol,2oo3 ,84 :353-360.

同被引文献36

  • 1王长法,张士璀,王昌留.水生无脊椎动物凝集素研究概述[J].海洋科学,2005,29(4):63-67. 被引量：18
  • 2王江勇,郭志勋,冯娟,刘广锋,徐力文,陈毕生,潘金培.养殖杂色鲍暴发病超微病理学研究[J].海洋科学,2007,31(3):28-32. 被引量：19
  • 3Takahashi K, Ezekowitz RA. The role of the mannose-binding lectin in innate immunity[J]. Clin Infect Dis, 2005, 41 Suppl 7: S440-444.
  • 4Bouwman LH, Roep BO, Roos A. Mannose-binding lectin: clinical implications for infection, transplantation, and autoimmunity[J]. Hum Immunol, 2006, 67(4-5): 247-256.
  • 5Madsen HO, GaiTed P, Thiel S, et al. Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein[J]. J Immunol, 1995, 155(6): 3013-3020.
  • 6Matsushita M, Thiel S, Jensenius JC, et al. Proteolytic activities of two types of mannose-binding lectin-assoeiated serine protease[J]. J Immunol, 2000, 165(5): 2637-2642.
  • 7Petersen SV, Thiel S, Jensen L, et al. Control of the classical and the MBL pathway of complement activatims{l]. MoI Immunol, 2000, 37(14): 803-811.
  • 8Kuhlman M, Joiner K, Ezekowitz RA. The human mannose-binding protein functions as an opsonin[J]. J Exp Med, 1989, 169(5): 1733-1745.
  • 9Malhotra R, Thiel S, Reid KB. Human leukocyte Clq receptor binds other soluble proteins with collagen domains [J]. J Exp Med, 1990, 172(3): 955-959.
  • 10Ghiran I, Barbashov SF, Kliekstein LB. Complement receptor 1/CD35 is a receptor for mannosc-binding lectin[J]. J Exp Med, 2000, 192(12): 1797-1808.

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鲁东大学学报（自然科学版）
2013年 第3期

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