摘要
目的:探讨冠心病(CHD)患者治疗前后血清妊娠相关蛋白A(PAPP-A)、血管细胞间黏附分子-1(ICAM-1)和超敏C-反应蛋白(hs-CRP)水平的临床应用价值。方法:采用化学放光法、酶联法和免疫比浊法对66例CHD患者进行了治疗前后血清PAPP-A、ICAM-1和hs-CRP检测,其中稳定型心绞痛(SAP)30例,不稳定型心绞痛(UAP)23例,急性心肌梗死(AMI)13例,并以35名正常健康人作比较。结果:CHD患者在治疗前血清PAPP-A、ICAM-1和hs-CRP水平均非常显著地高于正常人组(P<0.01),经中西医结合治疗3个月后则与正常人组比较无显著性差异(P>0.05)。结论:血清PAPP-A、ICAM-1和hs-CRP水平的变化与CHD的发生、发展密切相关。
Objective To explore the clinical values of serum PAPP-A,ICAM-1 and hs-CRP levels both before and after treatment in patients with coronary heart diseases.Methods Serum PAPP-A(with CLIA),serum ICAM-1(with ELISA) and serum hsCRP(with immunoturbidimetry) levels in 66 patients with coronary heart diseases both before and after treatment(30 SAP,23 UAP,13 AMI) and 35 normal healthy controls.Results Before treatment,serum PAPP-A,ICAM-1 and hs-CRP levels showed significantly higher than those in controls(P 0.01),after treatment for 3 months,those variables expressed about the same as in controls(P 0.05).Conclusion The serum PAPP-A,ICAM-1 and hs-CRP levels manifested well correlated to the development and progress of coronary heart diseases.
出处
《放射免疫学杂志》
CAS
2013年第4期467-469,共3页
Journal of Radioimmanology
关键词
冠心病
妊娠相关蛋白A
血管细胞间粘附分子-1
超敏C-反应蛋白
稳定型心绞痛
不稳定型心绞痛
急性心肌梗死
coronary heart diseases(CHD)
pregnancy-associated plasma protein-a(PAPP-A)
adhesion molecule-1
high sensitivity C-reactive protein(hs-CRP)
stable angina pectoris(SAP)
unstable angina pectoris(UAP)
acute myocardial infarction(AMI)