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CHD患者血清PAPP-A、ICAM-1和hs-CRP检测的临床价值 被引量:5

The Clinical Values of Serum PAPP-A,ICAM-1 and hs-CRP Levels in Patients with Coronary Heart Diseases
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摘要 目的:探讨冠心病(CHD)患者治疗前后血清妊娠相关蛋白A(PAPP-A)、血管细胞间黏附分子-1(ICAM-1)和超敏C-反应蛋白(hs-CRP)水平的临床应用价值。方法:采用化学放光法、酶联法和免疫比浊法对66例CHD患者进行了治疗前后血清PAPP-A、ICAM-1和hs-CRP检测,其中稳定型心绞痛(SAP)30例,不稳定型心绞痛(UAP)23例,急性心肌梗死(AMI)13例,并以35名正常健康人作比较。结果:CHD患者在治疗前血清PAPP-A、ICAM-1和hs-CRP水平均非常显著地高于正常人组(P<0.01),经中西医结合治疗3个月后则与正常人组比较无显著性差异(P>0.05)。结论:血清PAPP-A、ICAM-1和hs-CRP水平的变化与CHD的发生、发展密切相关。 Objective To explore the clinical values of serum PAPP-A,ICAM-1 and hs-CRP levels both before and after treatment in patients with coronary heart diseases.Methods Serum PAPP-A(with CLIA),serum ICAM-1(with ELISA) and serum hsCRP(with immunoturbidimetry) levels in 66 patients with coronary heart diseases both before and after treatment(30 SAP,23 UAP,13 AMI) and 35 normal healthy controls.Results Before treatment,serum PAPP-A,ICAM-1 and hs-CRP levels showed significantly higher than those in controls(P 0.01),after treatment for 3 months,those variables expressed about the same as in controls(P 0.05).Conclusion The serum PAPP-A,ICAM-1 and hs-CRP levels manifested well correlated to the development and progress of coronary heart diseases.
出处 《放射免疫学杂志》 CAS 2013年第4期467-469,共3页 Journal of Radioimmanology
关键词 冠心病 妊娠相关蛋白A 血管细胞间粘附分子-1 超敏C-反应蛋白 稳定型心绞痛 不稳定型心绞痛 急性心肌梗死 coronary heart diseases(CHD) pregnancy-associated plasma protein-a(PAPP-A) adhesion molecule-1 high sensitivity C-reactive protein(hs-CRP) stable angina pectoris(SAP) unstable angina pectoris(UAP) acute myocardial infarction(AMI)
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