期刊文献+

脓毒症致急性肾损伤的机制及治疗研究进展 被引量:33

原文传递
导出
摘要 脓毒症是指由细菌、病毒或真菌感染诱发的全身炎症反应,可以导致休克、多器官功能障碍综合征(MODS),甚至死亡。目前脓毒症已成为重症监护病房(ICU)患者死亡的主要原因,是1—4岁儿童的第7大致死原因和65~75岁老人的第8大致死原因。急性肾损伤(AKI)是脓毒症发展过程中最常见、最严重的并发症之一,以急性肾衰竭(ARF)为特征,表现为血液过滤不充分,水、离子调节及尿液产生障碍。
出处 《中华危重病急救医学》 CAS CSCD 北大核心 2013年第7期444-446,共3页 Chinese Critical Care Medicine
基金 国家自然科学基金(81101451) 广东省自然科学基金(S2011010003106) 广东省医学科学技术研究基金(B2011208)
  • 相关文献

参考文献25

  • 1The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference:definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis[J].Critical Care Medicine,1992.864-874.
  • 2Bagshaw SM,Uchino S,Bellomo R. Septic acute kidney injury in critically ill patients:clinical characteristics and outcomes[J].Clin J Am Soc Nephrol,2007.431-439.
  • 3Mayeux PR,MacMillan-Crow LA. Pharmacological targets in the renal peritubular microenvironment:implications for therapy for sepsis-induced acute kidney injury[J].Pharmacology and Therapeutics,2012.139-155.
  • 4Wesche-Soldato DE,Lomas-Neira JL,Perl M. The role and regulation of apoptosis in sepsis[J].Journal of Endotoxin Research,2005.375-382.
  • 5Lerolle N,Nochy D,Guérot E. Histopathology of septic shock induced acute kidney injury:apoptosis and leukocytic infiltration[J].Intensive Care Medicine,2010.471-478.
  • 6Hotchkiss RS,Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis[J].Nature Reviews Immunology,2006.813-822.
  • 7Jacobs R,Honore PM,Joannes-Boyau O. Septic acute kidney injury:the culprit is inflammatory apoptosis rather than ischemic necrosis[J].Blood Purification,2011.262-265.
  • 8Arany I. When less is more:apoptosis during acute kidney injury[J].Kidney International,2008.261-262.
  • 9Venkatachalam MA,Weinberg JM. The tubule pathology of septic acute kidney injury:a neglected area of research comes of age[J].Kidney International,2012.338-340.
  • 10孙成栋,张淑文,董军.脓毒症临床实验免疫指标研究进展[J].中国危重病急救医学,2005,17(12):760-763. 被引量:27

二级参考文献92

共引文献82

同被引文献442

引证文献33

二级引证文献296

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部