摘要
目的:观察连花清瘟胶囊治疗儿童流行性感冒(简称"流感")的疗效和安全性。方法:将128例流感患儿按照随机数字表法均分为观察组和对照组。观察组患儿给予连花清瘟胶囊治疗,每次0.70 mg,每日3次;对照组患儿给予双黄连口服液治疗,每次10 ml,每日2次。两组患儿均治疗7 d。观察两组患儿流感症状评分、感冒痊愈和退热平均时间、退热疗效、临床疗效以及不良反应。结果:治疗后,观察组患儿临床总有效率为93.75%,高于对照组的90.63%,但两组比较差异无统计学意义(P>0.05);观察组患儿退热总有效率为85.94%,对照组为62.50%,两组比较差异有统计学意义(P<0.05);观察组患儿感冒痊愈平均时间为(49.38±12.88)h,退热平均时间为(20.68±14.12)h,显著低于对照组([53.96±11.79)h和(25.77±13.96)h,P<0.05];观察组患儿头痛、咽痛咽干、肌肉酸痛的评分显著低于对照组,两组比较差异有统计学意义(P<0.05)。两组患儿治疗过程中均未见严重的不良反应发生。结论:连花清瘟胶囊治疗儿童流感疗效较好,可有效缓解头痛、咽痛咽干、肌肉酸痛等症状,痊愈时间和退热时间较短,安全性较好。
OBJECTIVE： To observe the clinical efficacy of Lianhua qingwen capsule in the treatment of pediatric epidemic in- fluenza. METHODS： 128 cases of pediatric epidemic influenza were randomly divided into observation group and control group, with 64 cases in each group. Observation group was given Lianhua qingwen capsule, 0.70 mg each time, 3 times a day, and con- trol group was given Shuanghuanglian oral liquid 10 ml, twice a day. 2 groups were treated for 7 days. The flu symptoms score, de- fervescence effect, dinical efficacy, average healing time , average defervescence time and ADR were compared between 2 groups. RESULTS： After treatment, the clinical total effective rate of observation group was 93.75%, which was higher than 90.63% in control group, but no difference was found between 2 groups（P〉0.05）. The total effective rate of cooling was 85.94% in observa- tion group and 62.50% in control group; there was significant difference between 2 groups（P〈0.05） ; the average healing time of observation group was （49.38 ± 12.88） h and the average defervescence time was （20.68 ± 14.12） h, which were significantly low- er than those of control group [（53.96 ± 11.79）h, （25.77 ± 13.96）h,P〈0.05]. The headache, sore throat, muscle pain score of ob- servation group was significantly lower than those of control group after treatment, the difference was statistically significant（P〈 0.05） in 2 groups. No serious adverse drug reactions was found in 2 groups. CONCLUSIONS： Lianhua qingwen capsule is effec- tive in the treatment of pediatric epidemic influenza, and relieve headache, sore throat, muscle pain and other symptoms with less ADR and good safety.
出处
《中国药房》
CAS
CSCD
2013年第28期2635-2637,共3页
China Pharmacy
关键词
流行性感冒
连花清瘟胶囊
疗效
安全性
Epidemic influenza
Lianhua qingwen capsule
Clinical efficacy
Safety
