摘要
以高纯度天然亚油酸为原料,通过碱催化异构化反应制得一种阴离子可聚合脂质——共轭亚油酸钠。在水溶液中使共轭亚油酸钠分子自组装成球状胶束,再经自由基引发剂引发胶束内部共轭亚油酸钠分子间自交联反应,最终获得共轭亚油酸钠的球状自交联胶束。探索了引发剂种类和用量、反应时间和温度等因素对共轭亚油酸钠分子自交联程度的影响,并采用TEM技术直观表征所获自交联组装体的形貌。结果表明,以过硫酸铵为引发剂,80℃下使pH=13的共轭亚油酸钠水溶液交联反应10 h可以得到平均粒径为20 nm的球状自交联胶束,这是一种潜在的稳定性纳米药物载体或微反应器。
A kind of anionic polymerizable lipids sodium conjugated linoleates was prepared from high purity natural linoleic acid through alkali catalytic isomerization reaction.The sodium conjugated linoleates molecularly self-assembled into spherical micelles in aqueous phase,and the intramicellar self-crosslinking reaction among the sodium conjugated linoleates was induced by some free radical initiators,resulting in the formation of spherical self-crosslinking micelles of sodium conjugated linoleates.The influence of such factors as type and amount of initiators,reaction time,and reaction temperature on the self-crosslinking degree of the sodium conjugated linoleates was investigated and the morphologies of the self-crosslinking assemblies were intuitively imaged by TEM.The experimental results indicate that the self-crosslinking spherical micelles of 20 nm in average diameter were obtained when the self-crosslinking was induced by using ammonium persulfate as initiator at pH=13 and 80 ℃ for 10 h.Those micelles can be a potential stable drug nanocarrier or microreactor.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2013年第7期729-733,共5页
Fine Chemicals
基金
国家自然科学基金(21276113)
江苏省高校研究生创新计划项目(CXZZ11_0467)
江南大学博士研究生科学研究基金(JUDCF10006)~~
关键词
共轭亚油酸钠
可聚合表面活性剂
自交联
胶束
自组装
sodium conjugated linoleate
polymerizable surfactant
self-crosslinking
micelle
self-assembling
