摘要
考察了噻托溴铵雾化吸入溶液经振动网式雾化器雾化形成的雾粒在3种口喉模型中的体外沉积行为。口喉模型种类、吸入气流模式及口喉模型内涂层等因素均影响雾粒在口喉模型中的沉积。在15和30 L/min下,噻托溴铵雾粒在理想口喉中的沉积量显著高于中国药典喉和美国药典喉;在模拟呼吸气流模式下的沉积量与15 L/min连续吸入气流模式相近,与30和60 L/min连续吸入气流模式差异显著;在有涂层口喉中的沉积量大于无涂层口喉。联用理想口喉模型和呼吸模拟器组成体外评价装置,可能更适于雾化吸入溶液的体外评价。
The in vitro deposition behavior of tiotropium inhalation solution after atomized by a vibrating-mesh nebulizer was investigated with three mouth-throat models. The mouth-throat models, patterns of inhalation airflow and inner coating on the models could significantly influence the deposition. The amount of tiotropium bromide deposited in idealized mouth-throat model was significantly higher than in Chinese pharmacopeia throat and USP （United States pharmacopeia） mouth-throat （induction port） when tested at continuous airflow of 15 and 30 L/min. The amount of deposition under breath simulator condition was similar to that under continuous airflow of 15 L/min, but was significantly different from middle and high speed （30 and 60 L/min） of continuous airflow patterns. The inner coating on idealized mouth-throat model could increase the tiotropium bromide deposition. A new in vitro evaluation apparatus might be designed by combination of the idealized mouth-throat model and breath simulator, which might be suitable for the in vitro evaluation of inhalation solutions.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2013年第7期677-680,共4页
Chinese Journal of Pharmaceuticals
基金
国家"重大新药创制"科技重大专项(2012ZX09304-004)
关键词
噻托溴铵
雾化吸入溶液
体外评价
理想口喉模型
呼吸模拟器
tiotropium bromide
inhalation solution
in vitro evaluation
idealized mouth-throat model
breathsimulator
